BDBM6222 8-Ethyl-2-ethylamino-8H-pyrido[2,3-d]pyrimidin-7-one::8-ethyl-2-(ethylamino)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 14

SMILES: CCNc1ncc2ccc(=O)n(CC)c2n1

InChI Key: InChIKey=PZIGHMJLTJTNDH-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6222   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM6222 (8-Ethyl-2-ethylamino-8H-pyrido[2,3-d]pyrimidin-7-o...) Show SMILES CCNc1ncc2ccc(=O)n(CC)c2n1 Show InChI InChI=1S/C11H14N4O/c1-3-12-11-13-7-8-5-6-9(16)15(4-2)10(8)14-11/h5-7H,3-4H2,1-2H3,(H,12,13,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	7.4	25
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
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