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SMILES: CCn1c2nc(NCc3ccccc3)ncc2ccc1=O

InChI Key: InChIKey=VGAGEGAWKUXMMZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6226   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]


(Homo sapiens (Human))		BDBM6226
PNG
(2-(benzylamino)-8-ethyl-7H,8H-pyrido[2,3-d]pyrimid...)
Show SMILES CCn1c2nc(NCc3ccccc3)ncc2ccc1=O
Show InChI InChI=1S/C16H16N4O/c1-2-20-14(21)9-8-13-11-18-16(19-15(13)20)17-10-12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,17,18,19)
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Article
PubMed
n/an/a>4.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...

J Med Chem 43: 4606-16 (2000)


Article DOI: 10.1021/jm000271k
BindingDB Entry DOI: 10.7270/Q25B00N4
More data for this
Ligand-Target Pair