BDBM6227 8-Ethyl-2-(methylphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one::8-ethyl-2-[methyl(phenyl)amino]-7H,8H-pyrido[2,3-d]pyrimidin-7-one::C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 19

SMILES: CCn1c2nc(ncc2ccc1=O)N(C)c1ccccc1

InChI Key: InChIKey=KNLUVRMEDJQLOQ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6227   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM6227 (8-Ethyl-2-(methylphenylamino)-8H-pyrido[2,3-d]pyri...) Show SMILES CCn1c2nc(ncc2ccc1=O)N(C)c1ccccc1 Show InChI InChI=1S/C16H16N4O/c1-3-20-14(21)10-9-12-11-17-16(18-15(12)20)19(2)13-7-5-4-6-8-13/h4-11H,3H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	7.4	25
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
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