BDBM6239 2-(4-Dimethylaminophenylamino)-8-ethyl-8H-pyrido-[2,3-d]pyrimidin-7-one::2-{[4-(dimethylamino)phenyl]amino}-8-ethyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one::C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 31
SMILES: CCn1c2nc(Nc3ccc(cc3)N(C)C)ncc2ccc1=O
InChI Key: InChIKey=DCPZNPCJNAXVMT-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human)) | BDBM6239 (2-(4-Dimethylaminophenylamino)-8-ethyl-8H-pyrido-[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Parke-Davis Pharmaceutical Research | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4 | |||||||||||
More data for this Ligand-Target Pair |