BDBM6248 2-(phenylamino)-8-propyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one::N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 40

SMILES: CCCn1c2nc(Nc3ccccc3)ncc2ccc1=O

InChI Key: InChIKey=ZEJXJYCOUVOWGJ-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6248   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM6248 (2-(phenylamino)-8-propyl-7H,8H-pyrido[2,3-d]pyrimi...) Show SMILES CCCn1c2nc(Nc3ccccc3)ncc2ccc1=O Show InChI InChI=1S/C16H16N4O/c1-2-10-20-14(21)9-8-12-11-17-16(19-15(12)20)18-13-6-4-3-5-7-13/h3-9,11H,2,10H2,1H3,(H,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	553	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM6248 (2-(phenylamino)-8-propyl-7H,8H-pyrido[2,3-d]pyrimi...) Show SMILES CCCn1c2nc(Nc3ccccc3)ncc2ccc1=O Show InChI InChI=1S/C16H16N4O/c1-2-10-20-14(21)9-8-12-11-17-16(19-15(12)20)18-13-6-4-3-5-7-13/h3-9,11H,2,10H2,1H3,(H,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	299	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM6248 (2-(phenylamino)-8-propyl-7H,8H-pyrido[2,3-d]pyrimi...) Show SMILES CCCn1c2nc(Nc3ccccc3)ncc2ccc1=O Show InChI InChI=1S/C16H16N4O/c1-2-10-20-14(21)9-8-12-11-17-16(19-15(12)20)18-13-6-4-3-5-7-13/h3-9,11H,2,10H2,1H3,(H,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
					More data for this Ligand-Target Pair
CDK2/CycE (Homo sapiens (Human))	BDBM6248 (2-(phenylamino)-8-propyl-7H,8H-pyrido[2,3-d]pyrimi...) Show SMILES CCCn1c2nc(Nc3ccccc3)ncc2ccc1=O Show InChI InChI=1S/C16H16N4O/c1-2-10-20-14(21)9-8-12-11-17-16(19-15(12)20)18-13-6-4-3-5-7-13/h3-9,11H,2,10H2,1H3,(H,17,18,19)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human))	BDBM6248 (2-(phenylamino)-8-propyl-7H,8H-pyrido[2,3-d]pyrimi...) Show SMILES CCCn1c2nc(Nc3ccccc3)ncc2ccc1=O Show InChI InChI=1S/C16H16N4O/c1-2-10-20-14(21)9-8-12-11-17-16(19-15(12)20)18-13-6-4-3-5-7-13/h3-9,11H,2,10H2,1H3,(H,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
					More data for this Ligand-Target Pair