BDBM6256 8-Bicyclo[2.2.1]hept-2-yl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::8-{bicyclo[2.2.1]heptan-2-yl}-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 48

SMILES: O=c1ccc2cnc(Nc3ccccc3)nc2n1C1CC2CCC1C2

InChI Key: InChIKey=QAWADIWIAIIMDV-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6256   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM6256 (8-Bicyclo[2.2.1]hept-2-yl-2-phenylamino-8H-pyrido[...) Show SMILES O=c1ccc2cnc(Nc3ccccc3)nc2n1C1CC2CCC1C2 |THB:17:18:21.22:24| Show InChI InChI=1S/C20H20N4O/c25-18-9-8-15-12-21-20(22-16-4-2-1-3-5-16)23-19(15)24(18)17-11-13-6-7-14(17)10-13/h1-5,8-9,12-14,17H,6-7,10-11H2,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
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