BDBM6264 (7-Oxo-2-phenylamino-7H-pyrido[2,3-d]pyrimidin-8-yl)acetic acid methyl ester::N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 56::methyl 2-[7-oxo-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimidin-8-yl]acetate
SMILES: COC(=O)Cn1c2nc(Nc3ccccc3)ncc2ccc1=O
InChI Key: InChIKey=VLXMQIWGAQUDQA-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human)) | BDBM6264 ((7-Oxo-2-phenylamino-7H-pyrido[2,3-d]pyrimidin-8-y...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research | Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... | J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4 | |||||||||||
More data for this Ligand-Target Pair |