BDBM6273 8-Cyclopropyl-2-[4-(4-methylpiperazin-1-yl)phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one::8-cyclopropyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 65

SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(C4CC4)c3n2)cc1

InChI Key: InChIKey=REDXWYHSSILFOH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6273   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM6273 (8-Cyclopropyl-2-[4-(4-methylpiperazin-1-yl)phenyla...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(C4CC4)c3n2)cc1 Show InChI InChI=1S/C21H24N6O/c1-25-10-12-26(13-11-25)17-5-3-16(4-6-17)23-21-22-14-15-2-9-19(28)27(18-7-8-18)20(15)24-21/h2-6,9,14,18H,7-8,10-13H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...				J Med Chem 43: 4606-16 (2000) Article DOI: 10.1021/jm000271k BindingDB Entry DOI: 10.7270/Q25B00N4
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