BDBM6400 5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-N-(3-hydroxy-propyl)-nicotinamide::5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}-N-(3-hydroxypropyl)pyridine-3-carboxamide::Pyrazine-Pyridine Biheteroaryl 43

SMILES: OCCCNC(=O)c1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1

InChI Key: InChIKey=CQKZPPUFUROCPO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6400   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Rattus norvegicus (rat))	BDBM6400 (5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-N-(3-hyd...) Show SMILES OCCCNC(=O)c1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C19H18ClN5O2/c20-15-3-1-4-16(8-15)24-18-12-22-11-17(25-18)13-7-14(10-21-9-13)19(27)23-5-2-6-26/h1,3-4,7-12,26H,2,5-6H2,(H,23,27)(H,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM6400 (5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-N-(3-hyd...) Show SMILES OCCCNC(=O)c1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C19H18ClN5O2/c20-15-3-1-4-16(8-15)24-18-12-22-11-17(25-18)13-7-14(10-21-9-13)19(27)23-5-2-6-26/h1,3-4,7-12,26H,2,5-6H2,(H,23,27)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair