BDBM6401 N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridin-3-yl)-2-hydroxyacetamide::N-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-yl}-2-hydroxy-acetamide::Pyrazine-Pyridine Biheteroaryl 44

SMILES: OCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1

InChI Key: InChIKey=LMHRDOSOBKKYLF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6401   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
VEGFR-2 (KDR) (Rattus norvegicus (rat))	BDBM6401 (N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...) Show SMILES OCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C17H14ClN5O2/c18-12-2-1-3-13(5-12)21-16-9-20-8-15(23-16)11-4-14(7-19-6-11)22-17(25)10-24/h1-9,24H,10H2,(H,21,23)(H,22,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	346	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM6401 (N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...) Show SMILES OCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C17H14ClN5O2/c18-12-2-1-3-13(5-12)21-16-9-20-8-15(23-16)11-4-14(7-19-6-11)22-17(25)10-24/h1-9,24H,10H2,(H,21,23)(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair