BDBM6402 N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridin-3-yl)-2-methoxyacetamide::N-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-yl}-2-methoxy-acetamide::Pyrazine-Pyridine Biheteroaryl 45
SMILES: COCC(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
InChI Key: InChIKey=JJEKRZADDFLKDS-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
VEGFR-2 (KDR) (Rattus norvegicus (rat)) | BDBM6402 (N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 303 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical | Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F... | J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human)) | BDBM6402 (N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical | Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F... | J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5 | |||||||||||
More data for this Ligand-Target Pair |