BDBM6405 N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridin-3-yl)-2-phenoxyacetamide::N-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-yl}-2-phenoxy-acetamide::Pyrazine-Pyridine Biheteroaryl 48

SMILES: Clc1cccc(Nc2cncc(n2)-c2cncc(NC(=O)COc3ccccc3)c2)c1

InChI Key: InChIKey=KMBNVVBGWONPFT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6405   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
VEGFR-2 (KDR) (Rattus norvegicus (rat))	BDBM6405 (N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...) Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NC(=O)COc3ccccc3)c2)c1 Show InChI InChI=1S/C23H18ClN5O2/c24-17-5-4-6-18(10-17)27-22-14-26-13-21(29-22)16-9-19(12-25-11-16)28-23(30)15-31-20-7-2-1-3-8-20/h1-14H,15H2,(H,27,29)(H,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM6405 (N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...) Show SMILES Clc1cccc(Nc2cncc(n2)-c2cncc(NC(=O)COc3ccccc3)c2)c1 Show InChI InChI=1S/C23H18ClN5O2/c24-17-5-4-6-18(10-17)27-22-14-26-13-21(29-22)16-9-19(12-25-11-16)28-23(30)15-31-20-7-2-1-3-8-20/h1-14H,15H2,(H,27,29)(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair