BDBM6424 3-[(6-chloro-5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridin-3-yl)amino]propan-1-ol::3-{6-Chloro-5-[6-(3-chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-ylamino}-propan-1-ol::Pyrazine-Pyridine Biheteroaryl 76

SMILES: OCCCNc1cnc(Cl)c(c1)-c1cncc(Nc2cccc(Cl)c2)n1

InChI Key: InChIKey=CWSMCLMKHVQLFW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6424   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
VEGFR-2 (KDR) (Rattus norvegicus (rat))	BDBM6424 (3-[(6-chloro-5-{6-[(3-chlorophenyl)amino]pyrazin-2...) Show SMILES OCCCNc1cnc(Cl)c(c1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C18H17Cl2N5O/c19-12-3-1-4-13(7-12)24-17-11-21-10-16(25-17)15-8-14(9-23-18(15)20)22-5-2-6-26/h1,3-4,7-11,22,26H,2,5-6H2,(H,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM6424 (3-[(6-chloro-5-{6-[(3-chlorophenyl)amino]pyrazin-2...) Show SMILES OCCCNc1cnc(Cl)c(c1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C18H17Cl2N5O/c19-12-3-1-4-13(7-12)24-17-11-21-10-16(25-17)15-8-14(9-23-18(15)20)22-5-2-6-26/h1,3-4,7-11,22,26H,2,5-6H2,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 4892-909 (2005) Article DOI: 10.1021/jm058205b BindingDB Entry DOI: 10.7270/Q2NC5ZD5
					More data for this Ligand-Target Pair