BDBM6431 3-[(6-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrazin-2-yl)amino]propan-1-ol::3-[[6 -((3-Chlorophenyl)amino)[2,2 ]bipyrazinyl-6-yl]-amino]propan-1ol::pyrazine-pyrazine deriv.38

SMILES: OCCCNc1cncc(n1)-c1cncc(Nc2cccc(Cl)c2)n1

InChI Key: InChIKey=FNULWBLUSGQXMP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6431   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
VEGFR-2 (KDR) (Rattus norvegicus (rat))	BDBM6431 (3-[(6-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyraz...) Show SMILES OCCCNc1cncc(n1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C17H17ClN6O/c18-12-3-1-4-13(7-12)22-17-11-20-9-15(24-17)14-8-19-10-16(23-14)21-5-2-6-25/h1,3-4,7-11,25H,2,5-6H2,(H,21,23)(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	497	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 1886-900 (2005) Article DOI: 10.1021/jm040099a BindingDB Entry DOI: 10.7270/Q2HM56NC
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM6431 (3-[(6-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyraz...) Show SMILES OCCCNc1cncc(n1)-c1cncc(Nc2cccc(Cl)c2)n1 Show InChI InChI=1S/C17H17ClN6O/c18-12-3-1-4-13(7-12)22-17-11-20-9-15(24-17)14-8-19-10-16(23-14)21-5-2-6-25/h1,3-4,7-11,25H,2,5-6H2,(H,21,23)(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	8.0	30
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...				J Med Chem 48: 1886-900 (2005) Article DOI: 10.1021/jm040099a BindingDB Entry DOI: 10.7270/Q2HM56NC
					More data for this Ligand-Target Pair