BDBM64546 4-ethyl-3-(2-methyl-5-thiophen-2-yl-thieno[2,3-d]pyrimidin-4-yl)sulfanyl-1H-1,2,4-triazol-5-one::4-ethyl-3-(2-methyl-5-thiophen-2-ylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1H-1,2,4-triazol-5-one::4-ethyl-3-[(2-methyl-5-thiophen-2-yl-4-thieno[2,3-d]pyrimidinyl)thio]-1H-1,2,4-triazol-5-one::4-ethyl-3-[[2-methyl-5-(2-thienyl)thieno[2,3-d]pyrimidin-4-yl]thio]-1H-1,2,4-triazol-5-one::MLS000056329::SMR000068446::cid_2559955
SMILES: CCn1c(Sc2nc(C)nc3scc(-c4cccs4)c23)n[nH]c1=O
InChI Key: InChIKey=KDEMIOZWVOAGJT-UHFFFAOYSA-N
Data: 4 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
heat shock protein 90 (Candida albicans) | BDBM64546 (4-ethyl-3-(2-methyl-5-thiophen-2-yl-thieno[2,3-d]p...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | PCBioAssay | n/a | n/a | n/a | n/a | >1.60E+5 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Keywords: Candida albicans, drug resistance, Fluconazole, Hsp90, Calcineurin, stress response Primary Collaborators: Susan Lindquist, Whitehead Insti... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2H41PWZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
heat shock protein 90 (Candida albicans) | BDBM64546 (4-ethyl-3-(2-methyl-5-thiophen-2-yl-thieno[2,3-d]p...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | PCBioAssay | n/a | n/a | n/a | n/a | 703 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Broad Institute: Reversing Antifungal Drug Resistance Project ID: 2037 Keywords: Candida albicans, drug resistance, Fluconazole, Hsp90, Calcineurin, ... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q26M358G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
heat shock protein 90 (Candida albicans) | BDBM64546 (4-ethyl-3-(2-methyl-5-thiophen-2-yl-thieno[2,3-d]p...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | PCBioAssay | n/a | n/a | n/a | n/a | 3.07E+4 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Keywords: Candida albicans, drug resistance, Fluconazole, Hsp90, stress response Assay Overview: Method for determining if compound acts as Hsp90 inh... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2V986HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
calcineurin A1, putative (Candida dubliniensis CD36) | BDBM64546 (4-ethyl-3-(2-methyl-5-thiophen-2-yl-thieno[2,3-d]p...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | PCBioAssay | n/a | n/a | n/a | n/a | 1.80E+5 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Keywords: Candida albicans, drug resistance, Fluconazole, calcineurin, stress response Assay Overview: Method for determining if compound acts as Ca... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2CC0Z46 | |||||||||||
More data for this Ligand-Target Pair |