BDBM64566 US9428505, Compound 10
SMILES: Cc1cc(cc(C)c1CCS(=O)(=O)N1CCC2(CC1)N=C(NC2=O)c1ccc(OC(F)(F)F)cc1)N1C(=O)NC(=O)C11COC1
InChI Key: InChIKey=WMHJWHBMOVKVON-UHFFFAOYSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Parathyroid hormone 1 receptor (PTH1R) (Rattus norvegicus (Rat)) | BDBM64566 (US9428505, Compound 10) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 1.20E+4 | n/a | n/a | 7.4 | n/a |
Chugai Seiyaku Kabushiki Kaisha US Patent | Assay Description Instead of HKRK-B7 cells, LLC-PK46_RATO_PTH1R cells overexpressing rat PTH1R, which were established at Chugai Pharmaceutical, were used to take meas... | US Patent US9428505 (2016) BindingDB Entry DOI: 10.7270/Q2VQ31KS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Parathyroid hormone (PTH) (Homo sapiens (Human)) | BDBM64566 (US9428505, Compound 10) | GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 2.10E+4 | n/a | n/a | 7.4 | n/a |
Chugai Seiyaku Kabushiki Kaisha US Patent | Assay Description HKRK-B7 or LLC-PK1 cells were seeded into a 96-well plate at 1×105 cells/well and incubated overnight. On the following day, 50 μl of cAMP assay... | US Patent US9428505 (2016) BindingDB Entry DOI: 10.7270/Q2VQ31KS | |||||||||||
More data for this Ligand-Target Pair |