Found 11 hits for monomerid = 6497 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM6497
(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)Show InChI InChI=1S/C19H21N3O5/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4/h6-10H,1-5H3,(H,20,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
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Similars
| Article PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Wyeth-Ayerst Research
| Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra... |
Bioorg Med Chem Lett 10: 2477-80 (2000)
Article DOI: 10.1016/S0960-894X(00)00493-5 BindingDB Entry DOI: 10.7270/Q20P0X7T |
More data for this Ligand-Target Pair | |
Macrophage colony stimulating factor receptor
(Homo sapiens (Human)) | BDBM6497
(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)Show InChI InChI=1S/C19H21N3O5/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4/h6-10H,1-5H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Antagonism towards Colony stimulating factor 1 receptor (CSF-1R) |
Bioorg Med Chem Lett 7: 421-424 (1997)
Article DOI: 10.1016/S0960-894X(97)00035-8 BindingDB Entry DOI: 10.7270/Q2SB45RN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM6497
(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)Show InChI InChI=1S/C19H21N3O5/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4/h6-10H,1-5H3,(H,20,21,22) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
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| Article
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of p56 lck tyrosine kinase |
Bioorg Med Chem Lett 7: 421-424 (1997)
Article DOI: 10.1016/S0960-894X(97)00035-8 BindingDB Entry DOI: 10.7270/Q2SB45RN |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM6497
(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)Show InChI InChI=1S/C19H21N3O5/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4/h6-10H,1-5H3,(H,20,21,22) | PDB MMDB
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CHEMBL PC cid PC sid UniChem
Patents
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| Article
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Antagonism towards Epidermal growth factor receptor |
Bioorg Med Chem Lett 7: 421-424 (1997)
Article DOI: 10.1016/S0960-894X(97)00035-8 BindingDB Entry DOI: 10.7270/Q2SB45RN |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM6497
(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)Show InChI InChI=1S/C19H21N3O5/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4/h6-10H,1-5H3,(H,20,21,22) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
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| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of p56lck kinase autophosphorylation in Jurkat cells |
Bioorg Med Chem Lett 7: 417-420 (1997)
Article DOI: 10.1016/S0960-894X(97)00034-6 BindingDB Entry DOI: 10.7270/Q2J966VN |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase GAK
(Homo sapiens (Human)) | BDBM6497
(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)Show InChI InChI=1S/C19H21N3O5/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4/h6-10H,1-5H3,(H,20,21,22) | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assay |
J Med Chem 62: 4772-4778 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00350 |
More data for this Ligand-Target Pair | |
PDGFR-beta/Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM6497
(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)Show InChI InChI=1S/C19H21N3O5/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4/h6-10H,1-5H3,(H,20,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
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Similars
| Article
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of platelet-derived growth factor receptor (PDGF-R) |
Bioorg Med Chem Lett 7: 421-424 (1997)
Article DOI: 10.1016/S0960-894X(97)00035-8 BindingDB Entry DOI: 10.7270/Q2SB45RN |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase GAK
(Homo sapiens (Human)) | BDBM6497
(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)Show InChI InChI=1S/C19H21N3O5/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4/h6-10H,1-5H3,(H,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan method |
J Med Chem 62: 4772-4778 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00350 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM6497
(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)Show InChI InChI=1S/C19H21N3O5/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4/h6-10H,1-5H3,(H,20,21,22) | PDB MMDB
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan method |
J Med Chem 62: 4772-4778 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00350 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM6497
(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)Show InChI InChI=1S/C19H21N3O5/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4/h6-10H,1-5H3,(H,20,21,22) | PDB MMDB
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CHEMBL PC cid PC sid UniChem
Patents
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| Article PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim... |
J Med Chem 62: 4772-4778 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00350 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM6497
(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)Show InChI InChI=1S/C19H21N3O5/c1-23-14-8-12-13(9-15(14)24-2)20-10-21-19(12)22-11-6-16(25-3)18(27-5)17(7-11)26-4/h6-10H,1-5H3,(H,20,21,22) | PDB MMDB
KEGG
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B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Epidermal growth factor receptor autophosphorylation. |
Bioorg Med Chem Lett 7: 417-420 (1997)
Article DOI: 10.1016/S0960-894X(97)00034-6 BindingDB Entry DOI: 10.7270/Q2J966VN |
More data for this Ligand-Target Pair | |