BindingDB logo
myBDB logout

null

SMILES: ONC(=O)CCCCn1cc(C(=O)Nc2ccncc2)c(=O)c2ccccc12

InChI Key: InChIKey=URDVCPWXGMFGAK-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 65468   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 1/11/4/6/8


(Homo sapiens (Human))		BDBM65468
PNG
(Quinolone-based HDAC inhibitor 4g)
Show SMILES ONC(=O)CCCCn1cc(C(=O)Nc2ccncc2)c(=O)c2ccccc12
Show InChI InChI=1S/C20H20N4O4/c25-18(23-28)7-3-4-12-24-13-16(19(26)15-5-1-2-6-17(15)24)20(27)22-14-8-10-21-11-9-14/h1-2,5-6,8-11,13,28H,3-4,7,12H2,(H,23,25)(H,21,22,27)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Orchid Chemicals & Pharmaceuticals Limited



Assay Description
Histone Deacetylase (HDAC) Inhibition Assay using Boc-Lys(Ac)-AMC Substrate: Inhibition of HDAC has been implicated to modulate transcription and to ...

J Enzyme Inhib Med Chem 29: 555-62 (2014)


Article DOI: 10.3109/14756366.2013.827675
BindingDB Entry DOI: 10.7270/Q22J6916
More data for this
Ligand-Target Pair