BDBM66977 3-[(3S,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,14-bis(oxidanyl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one::3-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one::Digitoxigenin::MLS002153810::SMR001233182::cid_4369270
SMILES: C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@]34C)[C@@]1(O)CC[C@@H]2C1=CC(=O)OC1
InChI Key: InChIKey=XZTUSOXSLKTKJQ-CESUGQOBSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Bcl-2-like protein 11 (Homo sapiens (Human)) | BDBM66977 (3-[(3S,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | >3.50E+5 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q24J0CKJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/potassium-transporting ATPase alpha-1 chain (Canis familiaris) | BDBM66977 (3-[(3S,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Prassis Istituto di Ricerche Sigma-Tau Curated by ChEMBL | Assay Description In vitro inhibitory concentration against dog kidney Na+,K+-ATPase | J Med Chem 43: 2332-49 (2000) BindingDB Entry DOI: 10.7270/Q2KP82VV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/potassium-transporting ATPase alpha-1 chain (Canis familiaris) | BDBM66977 (3-[(3S,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Prassis Istituto di Ricerche Sigma-Tau Curated by ChEMBL | Assay Description Inhibition of Na+/K+ ATPase from dog kidney | J Med Chem 40: 3484-8 (1997) Article DOI: 10.1021/jm970312l BindingDB Entry DOI: 10.7270/Q2SF2WVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium-transporting ATPase alpha chain 2 (Homo sapiens (Human)) | BDBM66977 (3-[(3S,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Prassis Istituto di Ricerche Sigma-Tau Curated by ChEMBL | Assay Description Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPase | J Med Chem 41: 3033-40 (1998) Article DOI: 10.1021/jm980108d BindingDB Entry DOI: 10.7270/Q2VX0H6K | |||||||||||
More data for this Ligand-Target Pair |