BDBM6719 1,4,14-triazaheptacyclo[16.7.1.0^{2,17}.0^{3,11}.0^{5,10}.0^{12,16}.0^{22,26}]hexacosa-2(17),3(11),5(10),6,8,12(16),18(26),19,21-nonaene-13,15-dione::1,7-Annulated indolocarbazole deriv. 6b

SMILES: O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1n3CCCc4cccc(c21)c34

InChI Key: InChIKey=ULAFGGWZPQSXLR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6719   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CDK2/CycE (Homo sapiens (Human))	BDBM6719 (1,4,14-triazaheptacyclo[16.7.1.0^{2,17}.0^{3,11}.0...) Show SMILES O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1n3CCCc4cccc(c21)c34 Show InChI InChI=1S/C23H15N3O2/c27-22-17-15-12-7-1-2-9-14(12)24-19(15)21-16(18(17)23(28)25-22)13-8-3-5-11-6-4-10-26(21)20(11)13/h1-3,5,7-9,24H,4,6,10H2,(H,25,27,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	25
Lilly Research Laboratories					Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....				Bioorg Med Chem Lett 14: 3217-20 (2004) Article DOI: 10.1016/j.bmcl.2004.03.105 BindingDB Entry DOI: 10.7270/Q2Q52MTT
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM6719 (1,4,14-triazaheptacyclo[16.7.1.0^{2,17}.0^{3,11}.0...) Show SMILES O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1n3CCCc4cccc(c21)c34 Show InChI InChI=1S/C23H15N3O2/c27-22-17-15-12-7-1-2-9-14(12)24-19(15)21-16(18(17)23(28)25-22)13-8-3-5-11-6-4-10-26(21)20(11)13/h1-3,5,7-9,24H,4,6,10H2,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	7.0	22
Lilly Research Laboratories					Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....				Bioorg Med Chem Lett 14: 3217-20 (2004) Article DOI: 10.1016/j.bmcl.2004.03.105 BindingDB Entry DOI: 10.7270/Q2Q52MTT
					More data for this Ligand-Target Pair