BDBM6754 1,7-Annulated indolocarbazole deriv. 13Bg::24-(hydroxymethyl)-9-methyl-1,9,14-triazaheptacyclo[16.7.1.0^{2,17}.0^{3,11}.0^{6,10}.0^{12,16}.0^{22,26}]hexacosa-2(17),3(11),4,6(10),7,12(16),18(26),19,21-nonaene-13,15-dione

SMILES: Cn1ccc2ccc3c4n5CC(CO)Cc6cccc(c4c4C(=O)NC(=O)c4c3c12)c56

InChI Key: InChIKey=FMZCXIHHKPGEAD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CDK2/CycE (Homo sapiens (Human))	BDBM6754 (1,7-Annulated indolocarbazole deriv. 13Bg | 24-(hy...) Show SMILES Cn1ccc2ccc3c4n5CC(CO)Cc6cccc(c4c4C(=O)NC(=O)c4c3c12)c56 Show InChI InChI=1S/C25H19N3O3/c1-27-8-7-13-5-6-16-17(22(13)27)19-20(25(31)26-24(19)30)18-15-4-2-3-14-9-12(11-29)10-28(21(14)15)23(16)18/h2-8,12,29H,9-11H2,1H3,(H,26,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	25
Lilly Research Laboratories					Assay Description In vitro assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP. 33P...				Bioorg Med Chem Lett 14: 3057-61 (2004) Article DOI: 10.1016/j.bmcl.2004.04.033 BindingDB Entry DOI: 10.7270/Q2KD1W3H
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM6754 (1,7-Annulated indolocarbazole deriv. 13Bg | 24-(hy...) Show SMILES Cn1ccc2ccc3c4n5CC(CO)Cc6cccc(c4c4C(=O)NC(=O)c4c3c12)c56 Show InChI InChI=1S/C25H19N3O3/c1-27-8-7-13-5-6-16-17(22(13)27)19-20(25(31)26-24(19)30)18-15-4-2-3-14-9-12(11-29)10-28(21(14)15)23(16)18/h2-8,12,29H,9-11H2,1H3,(H,26,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	7.0	22
Lilly Research Laboratories					Assay Description In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....				Bioorg Med Chem Lett 14: 3057-61 (2004) Article DOI: 10.1016/j.bmcl.2004.04.033 BindingDB Entry DOI: 10.7270/Q2KD1W3H
					More data for this Ligand-Target Pair