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BDBM6830 3-{2-[(4-hydroxycyclohexyl)amino]ethyl}-6-methoxy-18-methyl-3,13,18-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4(9),5,7,11(15),17(21),19,22-nonaene-12,14-dione::indolocarbazole deriv. 11m

SMILES: COc1ccc2c(c1)n(CCN[C@H]1CC[C@H](O)CC1)c1c2c2C(=O)NC(=O)c2c2c3n(C)ccc3ccc12

InChI Key: InChIKey=IDQNRCHDRUUOCX-IYARVYRRSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6830   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (human))
BDBM6830
PNG
(3-{2-[(4-hydroxycyclohexyl)amino]ethyl}-6-methoxy-...)
Show SMILES COc1ccc2c(c1)n(CCN[C@H]1CC[C@H](O)CC1)c1c2c2C(=O)NC(=O)c2c2c3n(C)ccc3ccc12
Show InChI InChI=1S/C30H30N4O4/c1-33-13-11-16-3-9-21-24(27(16)33)26-25(29(36)32-30(26)37)23-20-10-8-19(38-2)15-22(20)34(28(21)23)14-12-31-17-4-6-18(35)7-5-17/h3,8-11,13,15,17-18,31,35H,4-7,12,14H2,1-2H3,(H,32,36,37)/t17-,18-
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Article
PubMed
n/an/a 63n/an/an/an/an/an/a



Lilly Research Laboratories



Assay Description
In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....


Bioorg Med Chem Lett 13: 2261-7 (2003)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (human))
BDBM6830
PNG
(3-{2-[(4-hydroxycyclohexyl)amino]ethyl}-6-methoxy-...)
Show SMILES COc1ccc2c(c1)n(CCN[C@H]1CC[C@H](O)CC1)c1c2c2C(=O)NC(=O)c2c2c3n(C)ccc3ccc12
Show InChI InChI=1S/C30H30N4O4/c1-33-13-11-16-3-9-21-24(27(16)33)26-25(29(36)32-30(26)37)23-20-10-8-19(38-2)15-22(20)34(28(21)23)14-12-31-17-4-6-18(35)7-5-17/h3,8-11,13,15,17-18,31,35H,4-7,12,14H2,1-2H3,(H,32,36,37)/t17-,18-
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Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Lilly Research Laboratories



Assay Description
In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....


Bioorg Med Chem Lett 13: 2261-7 (2003)

More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6830
PNG
(3-{2-[(4-hydroxycyclohexyl)amino]ethyl}-6-methoxy-...)
Show SMILES COc1ccc2c(c1)n(CCN[C@H]1CC[C@H](O)CC1)c1c2c2C(=O)NC(=O)c2c2c3n(C)ccc3ccc12
Show InChI InChI=1S/C30H30N4O4/c1-33-13-11-16-3-9-21-24(27(16)33)26-25(29(36)32-30(26)37)23-20-10-8-19(38-2)15-22(20)34(28(21)23)14-12-31-17-4-6-18(35)7-5-17/h3,8-11,13,15,17-18,31,35H,4-7,12,14H2,1-2H3,(H,32,36,37)/t17-,18-
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Article
PubMed
n/an/a 1.17E+3n/an/an/an/an/an/a



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Bioorg Med Chem Lett 13: 2261-7 (2003)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM6830
PNG
(3-{2-[(4-hydroxycyclohexyl)amino]ethyl}-6-methoxy-...)
Show SMILES COc1ccc2c(c1)n(CCN[C@H]1CC[C@H](O)CC1)c1c2c2C(=O)NC(=O)c2c2c3n(C)ccc3ccc12
Show InChI InChI=1S/C30H30N4O4/c1-33-13-11-16-3-9-21-24(27(16)33)26-25(29(36)32-30(26)37)23-20-10-8-19(38-2)15-22(20)34(28(21)23)14-12-31-17-4-6-18(35)7-5-17/h3,8-11,13,15,17-18,31,35H,4-7,12,14H2,1-2H3,(H,32,36,37)/t17-,18-
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Article
PubMed
n/an/a 1.80E+4n/an/an/an/an/an/a



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Bioorg Med Chem Lett 13: 2261-7 (2003)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM6830
PNG
(3-{2-[(4-hydroxycyclohexyl)amino]ethyl}-6-methoxy-...)
Show SMILES COc1ccc2c(c1)n(CCN[C@H]1CC[C@H](O)CC1)c1c2c2C(=O)NC(=O)c2c2c3n(C)ccc3ccc12
Show InChI InChI=1S/C30H30N4O4/c1-33-13-11-16-3-9-21-24(27(16)33)26-25(29(36)32-30(26)37)23-20-10-8-19(38-2)15-22(20)34(28(21)23)14-12-31-17-4-6-18(35)7-5-17/h3,8-11,13,15,17-18,31,35H,4-7,12,14H2,1-2H3,(H,32,36,37)/t17-,18-
PDB

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antibodypedia
antibodypedia
antibodypedia
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PC sid
UniChem

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Article
PubMed
n/an/a 902n/an/an/an/an/an/a



Lilly Research Laboratories



Assay Description
In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....


Bioorg Med Chem Lett 13: 2261-7 (2003)

More data for this
Ligand-Target Pair