BDBM68334 3-amino-N-[5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazol-2-yl]pyrazinamide::3-amino-N-[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]pyrazine-2-carboxamide::3-amino-N-[5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-yl]-2-pyrazinecarboxamide::3-azanyl-N-[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]pyrazine-2-carboxamide::BRD-K38089706-001-01-9::cid_25475077
SMILES: Nc1nccnc1C(=O)Nc1nnc(SCc2ccc(Cl)cc2)s1
InChI Key: InChIKey=HJZJPIPXBHCPQV-UHFFFAOYSA-N
Data: 3 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
heat shock protein 90 (Candida albicans) | BDBM68334 (3-amino-N-[5-[(4-chlorobenzyl)thio]-1,3,4-thiadiaz...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | 1.43E+3 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Broad Institute: Reversing Antifungal Drug Resistance Project ID: 2037 Keywords: Candida albicans, drug resistance, fluconazole, Hsp90, Calcineurin, ... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2MC8XGG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
calcineurin A1, putative (Candida dubliniensis CD36) | BDBM68334 (3-amino-N-[5-[(4-chlorobenzyl)thio]-1,3,4-thiadiaz...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | >2.85E+5 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Keywords: Candida albicans, drug resistance, Fluconazole, calcineurin, stress response Assay Overview: Method for determining if compound acts as Ca... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2ZP44K0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
heat shock protein 90 (Candida albicans) | BDBM68334 (3-amino-N-[5-[(4-chlorobenzyl)thio]-1,3,4-thiadiaz...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | 1.91E+5 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Keywords: Candida albicans, drug resistance, Fluconazole, Hsp90, stress response Assay Overview: Method for determining if compound acts as Hsp90 inh... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2GM85R4 | |||||||||||
More data for this Ligand-Target Pair |