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BDBM6843 5-{2-[(2-hydroxyethyl)amino]ethyl}-18-methyl-3,13,18-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4(9),5,7,11(15),17(21),19,22-nonaene-12,14-dione::indolocarbazole deriv. 13h

SMILES: Cn1ccc2ccc3c4[nH]c5c(CCNCCO)cccc5c4c4C(=O)NC(=O)c4c3c12

InChI Key: InChIKey=BRGYPSBHCUNPNP-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6843   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (human))
BDBM6843
PNG
(5-{2-[(2-hydroxyethyl)amino]ethyl}-18-methyl-3,13,...)
Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCNCCO)cccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C25H22N4O3/c1-29-11-8-14-5-6-16-18(23(14)29)20-19(24(31)28-25(20)32)17-15-4-2-3-13(7-9-26-10-12-30)21(15)27-22(16)17/h2-6,8,11,26-27,30H,7,9-10,12H2,1H3,(H,28,31,32)
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Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Lilly Research Laboratories



Assay Description
In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....


Bioorg Med Chem Lett 13: 2261-7 (2003)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (human))
BDBM6843
PNG
(5-{2-[(2-hydroxyethyl)amino]ethyl}-18-methyl-3,13,...)
Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCNCCO)cccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C25H22N4O3/c1-29-11-8-14-5-6-16-18(23(14)29)20-19(24(31)28-25(20)32)17-15-4-2-3-13(7-9-26-10-12-30)21(15)27-22(16)17/h2-6,8,11,26-27,30H,7,9-10,12H2,1H3,(H,28,31,32)
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PC sid
UniChem

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Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Lilly Research Laboratories



Assay Description
In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....


Bioorg Med Chem Lett 13: 2261-7 (2003)

More data for this
Ligand-Target Pair
CaM Kinase II


(Rattus norvegicus (rat))
BDBM6843
PNG
(5-{2-[(2-hydroxyethyl)amino]ethyl}-18-methyl-3,13,...)
Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCNCCO)cccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C25H22N4O3/c1-29-11-8-14-5-6-16-18(23(14)29)20-19(24(31)28-25(20)32)17-15-4-2-3-13(7-9-26-10-12-30)21(15)27-22(16)17/h2-6,8,11,26-27,30H,7,9-10,12H2,1H3,(H,28,31,32)
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PC sid
UniChem

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Article
PubMed
n/an/a 95n/an/an/an/an/an/a



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Bioorg Med Chem Lett 13: 2261-7 (2003)

More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM6843
PNG
(5-{2-[(2-hydroxyethyl)amino]ethyl}-18-methyl-3,13,...)
Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCNCCO)cccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C25H22N4O3/c1-29-11-8-14-5-6-16-18(23(14)29)20-19(24(31)28-25(20)32)17-15-4-2-3-13(7-9-26-10-12-30)21(15)27-22(16)17/h2-6,8,11,26-27,30H,7,9-10,12H2,1H3,(H,28,31,32)
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Article
PubMed
n/an/a 6.12E+3n/an/an/an/an/an/a



Lilly Research Laboratories



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...


Bioorg Med Chem Lett 13: 2261-7 (2003)

More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))
BDBM6843
PNG
(5-{2-[(2-hydroxyethyl)amino]ethyl}-18-methyl-3,13,...)
Show SMILES Cn1ccc2ccc3c4[nH]c5c(CCNCCO)cccc5c4c4C(=O)NC(=O)c4c3c12
Show InChI InChI=1S/C25H22N4O3/c1-29-11-8-14-5-6-16-18(23(14)29)20-19(24(31)28-25(20)32)17-15-4-2-3-13(7-9-26-10-12-30)21(15)27-22(16)17/h2-6,8,11,26-27,30H,7,9-10,12H2,1H3,(H,28,31,32)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 265n/an/an/an/an/an/a



Lilly Research Laboratories



Assay Description
In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....


Bioorg Med Chem Lett 13: 2261-7 (2003)

More data for this
Ligand-Target Pair