BDBM7074 (4R,5S,6S,7R)-4,7-bis[(4-fluorophenyl)methyl]-5,6-dihydroxy-1,3-bis({[4-(hydroxymethyl)phenyl]methyl})-1,3-diazepan-2-one::(4R,5S,6S,7R)-Hexahydro-5,6-dihydroxy-1,3-bis-[[4-(hydroxymethyl)phenyl]methyl]-4,7-bis[(4-fluorophenyl)methyl]-2H-1,3-diazapin-2-one::Substituted Cyclic Urea 64
SMILES: OCc1ccc(CN2[C@H](Cc3ccc(F)cc3)[C@H](O)[C@@H](O)[C@@H](Cc3ccc(F)cc3)N(Cc3ccc(CO)cc3)C2=O)cc1
InChI Key: InChIKey=PSHUCZKRZJVSPI-WZJLIZBTSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM7074 ((4R,5S,6S,7R)-4,7-bis[(4-fluorophenyl)methyl]-5,6-...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.440 | -13.3 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | Bioorg Med Chem Lett 8: 1077-82 (1998) Article DOI: 10.1016/s0960-894x(98)00175-9 BindingDB Entry DOI: 10.7270/Q21G0JGN | |||||||||||
More data for this Ligand-Target Pair |