BDBM70876 US9546164, 50::US9694002, 50::US9694002, 51

SMILES: C[C@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=GEVQKHWJSOLJFV-IFXJQAMLSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 70876   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium Channel Complex (Homo sapiens (Human))	BDBM70876 (US9546164, 50 | US9694002, 50 | US9694002, 51) Show SMILES C[C@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C24H27Cl2FN2O4S/c1-14(16-8-17(25)10-18(26)9-16)29-7-3-4-19(13-29)33-23-12-22(27)21(11-20(23)15-5-6-15)24(30)28-34(2,31)32/h8-12,14-15,19H,3-7,13H2,1-2H3,(H,28,30)/t14-,19+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM70876 (US9546164, 50 | US9694002, 50 | US9694002, 51) Show SMILES C[C@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C24H27Cl2FN2O4S/c1-14(16-8-17(25)10-18(26)9-16)29-7-3-4-19(13-29)33-23-12-22(27)21(11-20(23)15-5-6-15)24(30)28-34(2,31)32/h8-12,14-15,19H,3-7,13H2,1-2H3,(H,28,30)/t14-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...				US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM70876 (US9546164, 50 | US9694002, 50 | US9694002, 51) Show SMILES C[C@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C24H27Cl2FN2O4S/c1-14(16-8-17(25)10-18(26)9-16)29-7-3-4-19(13-29)33-23-12-22(27)21(11-20(23)15-5-6-15)24(30)28-34(2,31)32/h8-12,14-15,19H,3-7,13H2,1-2H3,(H,28,30)/t14-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...				US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4
					More data for this Ligand-Target Pair
Sodium Channel Complex (Homo sapiens (Human))	BDBM70876 (US9546164, 50 | US9694002, 50 | US9694002, 51) Show SMILES C[C@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C24H27Cl2FN2O4S/c1-14(16-8-17(25)10-18(26)9-16)29-7-3-4-19(13-29)33-23-12-22(27)21(11-20(23)15-5-6-15)24(30)28-34(2,31)32/h8-12,14-15,19H,3-7,13H2,1-2H3,(H,28,30)/t14-,19+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
					More data for this Ligand-Target Pair