BDBM71224 US9546164, 323::US9694002, 323

SMILES: C[C@@H]1CC[C@H](CN1Cc1ccc(F)cc1Cl)Oc1cc(F)c(cc1C1CC1)C(=O)NS(=O)(=O)C1CC1

InChI Key: InChIKey=PPNSUOZZLIDACH-DNVCBOLYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 71224   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM71224 (US9546164, 323 | US9694002, 323) Show SMILES C[C@@H]1CC[C@H](CN1Cc1ccc(F)cc1Cl)Oc1cc(F)c(cc1C1CC1)C(=O)NS(=O)(=O)C1CC1 |r| Show InChI InChI=1S/C26H29ClF2N2O4S/c1-15-2-7-19(14-31(15)13-17-5-6-18(28)10-23(17)27)35-25-12-24(29)22(11-21(25)16-3-4-16)26(32)30-36(33,34)20-8-9-20/h5-6,10-12,15-16,19-20H,2-4,7-9,13-14H2,1H3,(H,30,32)/t15-,19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...				US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4
					More data for this Ligand-Target Pair
Sodium Channel Complex (Homo sapiens (Human))	BDBM71224 (US9546164, 323 | US9694002, 323) Show SMILES C[C@@H]1CC[C@H](CN1Cc1ccc(F)cc1Cl)Oc1cc(F)c(cc1C1CC1)C(=O)NS(=O)(=O)C1CC1 |r| Show InChI InChI=1S/C26H29ClF2N2O4S/c1-15-2-7-19(14-31(15)13-17-5-6-18(28)10-23(17)27)35-25-12-24(29)22(11-21(25)16-3-4-16)26(32)30-36(33,34)20-8-9-20/h5-6,10-12,15-16,19-20H,2-4,7-9,13-14H2,1H3,(H,30,32)/t15-,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
					More data for this Ligand-Target Pair