null

SMILES: CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CN(C1)C(c1ccccc1)c1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=IPZMXZLTFKXKRB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 71350   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM71350 (US9546164, 421 | US9694002, 421) Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CN(C1)C(c1ccccc1)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C31H31Cl2FN2O4S/c1-31(16-36(17-31)29(20-5-3-2-4-6-20)21-11-22(32)13-23(33)12-21)18-40-28-15-27(34)26(14-25(28)19-7-8-19)30(37)35-41(38,39)24-9-10-24/h2-6,11-15,19,24,29H,7-10,16-18H2,1H3,(H,35,37)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...				US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4
					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM71350 (US9546164, 421 | US9694002, 421) Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CN(C1)C(c1ccccc1)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C31H31Cl2FN2O4S/c1-31(16-36(17-31)29(20-5-3-2-4-6-20)21-11-22(32)13-23(33)12-21)18-40-28-15-27(34)26(14-25(28)19-7-8-19)30(37)35-41(38,39)24-9-10-24/h2-6,11-15,19,24,29H,7-10,16-18H2,1H3,(H,35,37)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
					More data for this Ligand-Target Pair