BDBM7256 (3Z)-2-oxo-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-c]pyridin-1-yl}methylidene)-2,3-dihydro-1H-indole-5-carboxylic acid::pyrrollylactam indolinone driv. 16f

SMILES: OC(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1

InChI Key: InChIKey=QEJMEZANRAPVRH-WDZFZDKYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 7256   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CDK2/CycE (Homo sapiens (Human))	BDBM7256 ((3Z)-2-oxo-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-c]...) Show SMILES OC(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1 Show InChI InChI=1S/C17H13N3O4/c21-15-12-7-19-14(9(12)3-4-18-15)6-11-10-5-8(17(23)24)1-2-13(10)20-16(11)22/h1-2,5-7,19H,3-4H2,(H,18,21)(H,20,22)(H,23,24)/b11-6-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair