BDBM7258 (3Z)-5-bromo-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-c]pyridin-1-yl}methylidene)-2,3-dihydro-1H-indol-2-one::pyrrollylactam indolinone driv. 16i

SMILES: Brc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1

InChI Key: InChIKey=GPZPJEOUNUIIMR-WDZFZDKYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 7258   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CDK2/CycE (Homo sapiens (Human))	BDBM7258 ((3Z)-5-bromo-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-...) Show SMILES Brc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1 Show InChI InChI=1S/C16H12BrN3O2/c17-8-1-2-13-10(5-8)11(16(22)20-13)6-14-9-3-4-18-15(21)12(9)7-19-14/h1-2,5-7,19H,3-4H2,(H,18,21)(H,20,22)/b11-6-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair