BDBM7260 (3Z)-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-c]pyridin-1-yl}methylidene)-4-(piperidin-4-yl)-2,3-dihydro-1H-indol-2-one::pyrrollylactam indolinone driv. 16l

SMILES: O=C1Nc2cccc(C3CCNCC3)c2\C1=C\c1[nH]cc2c1CCNC2=O

InChI Key: InChIKey=ORMCURCBAUGAQD-GDNBJRDFSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 7260   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CDK2/CycE (Homo sapiens (Human))	BDBM7260 ((3Z)-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-c]pyridi...) Show SMILES O=C1Nc2cccc(C3CCNCC3)c2\C1=C\c1[nH]cc2c1CCNC2=O Show InChI InChI=1S/C21H22N4O2/c26-20-16-11-24-18(14(16)6-9-23-20)10-15-19-13(12-4-7-22-8-5-12)2-1-3-17(19)25-21(15)27/h1-3,10-12,22,24H,4-9H2,(H,23,26)(H,25,27)/b15-10-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
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