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SMILES: COc1ccc(cc1)-c1[nH]c2nccnc2c1C

InChI Key: InChIKey=ZUHJPCPWABPZDY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7358   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Rattus norvegicus (rat))	BDBM7358 (6-(4-Methoxyphenyl)-7-methyl[5H]pyrrolo[2,3-b]pyra...) Show SMILES COc1ccc(cc1)-c1[nH]c2nccnc2c1C Show InChI InChI=1S/C14H13N3O/c1-9-12(10-3-5-11(18-2)6-4-10)17-14-13(9)15-7-8-16-14/h3-8H,1-2H3,(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha/beta (Homo sapiens (Human))	BDBM7358 (6-(4-Methoxyphenyl)-7-methyl[5H]pyrrolo[2,3-b]pyra...) Show SMILES COc1ccc(cc1)-c1[nH]c2nccnc2c1C Show InChI InChI=1S/C14H13N3O/c1-9-12(10-3-5-11(18-2)6-4-10)17-14-13(9)15-7-8-16-14/h3-8H,1-2H3,(H,16,17)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	457	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibitory concentration against Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 395-9 (2005) Article DOI: 10.1016/j.bmcl.2004.10.060 BindingDB Entry DOI: 10.7270/Q2WH2SR0
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM7358 (6-(4-Methoxyphenyl)-7-methyl[5H]pyrrolo[2,3-b]pyra...) Show SMILES COc1ccc(cc1)-c1[nH]c2nccnc2c1C Show InChI InChI=1S/C14H13N3O/c1-9-12(10-3-5-11(18-2)6-4-10)17-14-13(9)15-7-8-16-14/h3-8H,1-2H3,(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Marthasterias glacialis (starfish))	BDBM7358 (6-(4-Methoxyphenyl)-7-methyl[5H]pyrrolo[2,3-b]pyra...) Show SMILES COc1ccc(cc1)-c1[nH]c2nccnc2c1C Show InChI InChI=1S/C14H13N3O/c1-9-12(10-3-5-11(18-2)6-4-10)17-14-13(9)15-7-8-16-14/h3-8H,1-2H3,(H,16,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair