BDBM7362 6-(4-methoxyphenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine::6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 36::7-Isopropyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine

SMILES: COc1ccc(cc1)-c1[nH]c2nccnc2c1C(C)C

InChI Key: InChIKey=CAFYKPIUWNVPMG-UHFFFAOYSA-N

Data: 4 IC50

PDB links: 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7362   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM7362 (6-(4-methoxyphenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3...) Show SMILES COc1ccc(cc1)-c1[nH]c2nccnc2c1C(C)C Show InChI InChI=1S/C16H17N3O/c1-10(2)13-14(11-4-6-12(20-3)7-5-11)19-16-15(13)17-8-9-18-16/h4-10H,1-3H3,(H,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha/beta (Homo sapiens (Human))	BDBM7362 (6-(4-methoxyphenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3...) Show SMILES COc1ccc(cc1)-c1[nH]c2nccnc2c1C(C)C Show InChI InChI=1S/C16H17N3O/c1-10(2)13-14(11-4-6-12(20-3)7-5-11)19-16-15(13)17-8-9-18-16/h4-10H,1-3H3,(H,18,19)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	501	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibitory concentration against Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 395-9 (2005) Article DOI: 10.1016/j.bmcl.2004.10.060 BindingDB Entry DOI: 10.7270/Q2WH2SR0
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Marthasterias glacialis (starfish))	BDBM7362 (6-(4-methoxyphenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3...) Show SMILES COc1ccc(cc1)-c1[nH]c2nccnc2c1C(C)C Show InChI InChI=1S/C16H17N3O/c1-10(2)13-14(11-4-6-12(20-3)7-5-11)19-16-15(13)17-8-9-18-16/h4-10H,1-3H3,(H,18,19)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Rattus norvegicus (rat))	BDBM7362 (6-(4-methoxyphenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3...) Show SMILES COc1ccc(cc1)-c1[nH]c2nccnc2c1C(C)C Show InChI InChI=1S/C16H17N3O/c1-10(2)13-14(11-4-6-12(20-3)7-5-11)19-16-15(13)17-8-9-18-16/h4-10H,1-3H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	30
Faculte de Medecine et de Pharmacie					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 46: 222-36 (2003) Article DOI: 10.1021/jm020319p BindingDB Entry DOI: 10.7270/Q2474820
					More data for this Ligand-Target Pair