BDBM7413 (2 Z,3 E)-6-Vinylindirubin-3 -oxime::6-ethenyl-3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2-ylidene]-2,3-dihydro-1H-indol-2-one::6-vinylindirubin-3 -oxime::indirubin deriv. 7i

SMILES: C=Cc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O

InChI Key: InChIKey=YGSQDSWZESKDIQ-UHFFFAOYSA-N

Data: 3 IC50

PDB links: 3 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7413   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM7413 ((2 Z,3 E)-6-Vinylindirubin-3 -oxime | 6-ethenyl-3-...) Show SMILES C=Cc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O Show InChI InChI=1S/C18H13N3O2/c1-2-10-7-8-11-14(9-10)20-18(22)15(11)17-16(21-23)12-5-3-4-6-13(12)19-17/h2-9,15,19H,1H2,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	30
University of Athens					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 935-46 (2004) Article DOI: 10.1021/jm031016d BindingDB Entry DOI: 10.7270/Q20G3HB8
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Marthasterias glacialis (starfish))	BDBM7413 ((2 Z,3 E)-6-Vinylindirubin-3 -oxime | 6-ethenyl-3-...) Show SMILES C=Cc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O Show InChI InChI=1S/C18H13N3O2/c1-2-10-7-8-11-14(9-10)20-18(22)15(11)17-16(21-23)12-5-3-4-6-13(12)19-17/h2-9,15,19H,1H2,(H,20,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	30
University of Athens					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 935-46 (2004) Article DOI: 10.1021/jm031016d BindingDB Entry DOI: 10.7270/Q20G3HB8
					More data for this Ligand-Target Pair
Glycogen Synthase Kinase-3, beta (Porcine)	BDBM7413 ((2 Z,3 E)-6-Vinylindirubin-3 -oxime | 6-ethenyl-3-...) Show SMILES C=Cc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O Show InChI InChI=1S/C18H13N3O2/c1-2-10-7-8-11-14(9-10)20-18(22)15(11)17-16(21-23)12-5-3-4-6-13(12)19-17/h2-9,15,19H,1H2,(H,20,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	30
University of Athens					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 935-46 (2004) Article DOI: 10.1021/jm031016d BindingDB Entry DOI: 10.7270/Q20G3HB8
					More data for this Ligand-Target Pair