BDBM75025 4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile::4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio)-6-oxo-5-pyrimidinecarbonitrile::4-[4-(dimethylamino)phenyl]-1-methyl-2-methylsulfanyl-6-oxidanylidene-pyrimidine-5-carbonitrile::4-[4-(dimethylamino)phenyl]-1-methyl-2-methylsulfanyl-6-oxopyrimidine-5-carbonitrile::4-[4-(dimethylamino)phenyl]-6-keto-1-methyl-2-(methylthio)pyrimidine-5-carbonitrile::MLS000766800::SMR000339696::cid_694212

SMILES: CSc1nc(-c2ccc(cc2)N(C)C)c(C#N)c(=O)n1C

InChI Key: InChIKey=YWJYAWQVXOGURC-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 75025   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Importin subunit alpha-1 (Homo sapiens (Human))	BDBM75025 (4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio...) Show SMILES CSc1nc(-c2ccc(cc2)N(C)C)c(C#N)c(=O)n1C Show InChI InChI=1S/C15H16N4OS/c1-18(2)11-7-5-10(6-8-11)13-12(9-16)14(20)19(3)15(17-13)21-4/h5-8H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PCBioAssay	n/a	n/a	n/a	n/a	9.42E+3	n/a	n/a	n/a	n/a
Broad Institute Curated by PubChem BioAssay					Assay Description Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q280513R
					More data for this Ligand-Target Pair
Corticotropin-releasing factor-binding protein (Homo sapiens (Human))	BDBM75025 (4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio...) Show SMILES CSc1nc(-c2ccc(cc2)N(C)C)c(C#N)c(=O)n1C Show InChI InChI=1S/C15H16N4OS/c1-18(2)11-7-5-10(6-8-11)13-12(9-16)14(20)19(3)15(17-13)21-4/h5-8H,1-4H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PCBioAssay	n/a	n/a	n/a	n/a	7.08E+3	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2012) BindingDB Entry DOI: 10.7270/Q2VX0F3D
					More data for this Ligand-Target Pair
Endoribonuclease toxin MazF (Escherichia coli str. K-12 substr. MG1655)	BDBM75025 (4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio...) Show SMILES CSc1nc(-c2ccc(cc2)N(C)C)c(C#N)c(=O)n1C Show InChI InChI=1S/C15H16N4OS/c1-18(2)11-7-5-10(6-8-11)13-12(9-16)14(20)19(3)15(17-13)21-4/h5-8H,1-4H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PCBioAssay	n/a	n/a	n/a	n/a	>9.90E+4	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2Z31X54
					More data for this Ligand-Target Pair
Endoribonuclease toxin MazF (Escherichia coli str. K-12 substr. MG1655)	BDBM75025 (4-[4-(dimethylamino)phenyl]-1-methyl-2-(methylthio...) Show SMILES CSc1nc(-c2ccc(cc2)N(C)C)c(C#N)c(=O)n1C Show InChI InChI=1S/C15H16N4OS/c1-18(2)11-7-5-10(6-8-11)13-12(9-16)14(20)19(3)15(17-13)21-4/h5-8H,1-4H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PCBioAssay	n/a	n/a	n/a	n/a	>9.90E+4	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2TB15DB
					More data for this Ligand-Target Pair