BDBM7661 N-[2-(dimethylamino)ethyl]-4-[(4-{imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-yl)amino]benzene-1-sulfonamide::sulfonamide deriv. 3d
SMILES: CN(C)CCNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3ccccn23)cc1
InChI Key: InChIKey=HYBCPKCAHCAFSQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human)) | BDBM7661 (N-[2-(dimethylamino)ethyl]-4-[(4-{imidazo[1,2-a]py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 260 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca | Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. | Bioorg Med Chem Lett 14: 2245-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.015 BindingDB Entry DOI: 10.7270/Q22805TT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM7661 (N-[2-(dimethylamino)ethyl]-4-[(4-{imidazo[1,2-a]py...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca | Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. | Bioorg Med Chem Lett 14: 2245-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.015 BindingDB Entry DOI: 10.7270/Q22805TT | |||||||||||
More data for this Ligand-Target Pair |