BDBM769 4-hydroxy-2-pyrone 6::4-hydroxy-6-(2-phenylethyl)-3-(1-phenylpropyl)-2H-pyran-2-one
SMILES: CCC(c1ccccc1)c1c(O)cc(CCc2ccccc2)oc1=O
InChI Key: InChIKey=OAXPPAUXOZJCFF-UHFFFAOYSA-N
Data: 1 KI
PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM769 (4-hydroxy-2-pyrone 6 | 4-hydroxy-6-(2-phenylethyl)...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn | Assay Description HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K... | J Med Chem 37: 3200-4 (1994) Article DOI: 10.1021/jm00046a002 BindingDB Entry DOI: 10.7270/Q2KK98XK | |||||||||||
More data for this Ligand-Target Pair |