BDBM7822 1,3-thiazolidine-2,4-dione::CHEMBL2071163::thiazolidinedione deriv. 21
SMILES: Oc1csc(=O)[nH]1
InChI Key: InChIKey=MQYUOKQDHLEQAC-UHFFFAOYSA-N
PDB links: 5 PDB IDs contain this monomer as substructures. 8 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM7822 (1,3-thiazolidine-2,4-dione | CHEMBL2071163 | thiaz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of KDM4C catalytic core-mediated demethylation of ARK(Me)3STGGK after 30 mins by FDH-coupled assay | Bioorg Med Chem Lett 22: 5811-3 (2012) Article DOI: 10.1016/j.bmcl.2012.07.091 BindingDB Entry DOI: 10.7270/Q2222VV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM7822 (1,3-thiazolidine-2,4-dione | CHEMBL2071163 | thiaz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of KDM4C catalytic core-mediated demethylation of ARK(Me)3STGGK after 30 mins by FDH-coupled assay | Bioorg Med Chem Lett 22: 5811-3 (2012) Article DOI: 10.1016/j.bmcl.2012.07.091 BindingDB Entry DOI: 10.7270/Q2222VV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen Synthase Kinase-3, beta (Oryctolagus cuniculus (rabbit)) | BDBM7822 (1,3-thiazolidine-2,4-dione | CHEMBL2071163 | thiaz...) | GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | 37 |
Instituto de Quimica Medica (CSIC) | Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32... | J Med Chem 48: 7103-12 (2005) Article DOI: 10.1021/jm040895g BindingDB Entry DOI: 10.7270/Q2J964MP | |||||||||||
More data for this Ligand-Target Pair |