BDBM80643 (6R,7S)-7-[[4-(2-amino-1-carboxy-2-keto-ethylidene)-1,3-dithietane-2-carbonyl]amino]-8-keto-7-methoxy-3-[[(1-methyltetrazol-5-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid::(6R,7S)-7-[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid::(6R,7S)-7-[[4-[1-azanyl-3-oxidanyl-1,3-bis(oxidanylidene)propan-2-ylidene]-1,3-dithietan-2-yl]carbonylamino]-7-methoxy-3-[(1-methyl-1,2,3,4-tetrazol-5-yl)sulfanylmethyl]-8-oxidanylidene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid::(6R,7S)-7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]-oxomethyl]amino]-7-methoxy-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid::Cefotetan::MLS002153829::SMR001233197::cid_53025

SMILES: CO[C@]1(NC(=O)C2SC(S2)=C(C(N)=O)C(O)=O)[C@H]2SCC(CSc3nnnn3C)=C(N2C1=O)C(O)=O

InChI Key: InChIKey=SRZNHPXWXCNNDU-IXOPCIAXSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 80643   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
probable DNA dC->dU-editing enzyme APOBEC-3A (Homo sapiens (Human))	BDBM80643 ((6R,7S)-7-[[4-(2-amino-1-carboxy-2-keto-ethylidene...) Show SMILES CO[C@]1(NC(=O)C2SC(S2)=C(C(N)=O)C(O)=O)[C@H]2SCC(CSc3nnnn3C)=C(N2C1=O)C(O)=O |wU:17.32,2.2,wD:2.1,c:30,(12.4,-3.66,;13.74,-2.89,;13.74,-1.35,;15.28,-1.35,;16.05,-2.69,;15.27,-4.02,;17.59,-2.69,;17.59,-1.15,;19.13,-1.15,;19.13,-2.69,;20.22,-.07,;21.71,-.47,;22.8,.62,;22.1,-1.96,;19.82,1.42,;20.92,2.51,;18.34,1.82,;12.19,-1.34,;10.85,-2.11,;9.52,-1.34,;9.52,.2,;8.18,.97,;6.85,.2,;5.52,.97,;4.11,.34,;3.08,1.48,;3.85,2.82,;5.36,2.5,;6.5,3.53,;10.85,.97,;12.19,.2,;13.74,.2,;14.83,1.29,;10.85,2.51,;9.52,3.28,;12.19,3.28,)| Show InChI InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	2.96E+4	n/a	n/a	n/a	n/a	n/a	25
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q24F1P6P
					More data for this Ligand-Target Pair
DNA dC->dU-editing enzyme APOBEC-3G (Homo sapiens (Human))	BDBM80643 ((6R,7S)-7-[[4-(2-amino-1-carboxy-2-keto-ethylidene...) Show SMILES CO[C@]1(NC(=O)C2SC(S2)=C(C(N)=O)C(O)=O)[C@H]2SCC(CSc3nnnn3C)=C(N2C1=O)C(O)=O |wU:17.32,2.2,wD:2.1,c:30,(12.4,-3.66,;13.74,-2.89,;13.74,-1.35,;15.28,-1.35,;16.05,-2.69,;15.27,-4.02,;17.59,-2.69,;17.59,-1.15,;19.13,-1.15,;19.13,-2.69,;20.22,-.07,;21.71,-.47,;22.8,.62,;22.1,-1.96,;19.82,1.42,;20.92,2.51,;18.34,1.82,;12.19,-1.34,;10.85,-2.11,;9.52,-1.34,;9.52,.2,;8.18,.97,;6.85,.2,;5.52,.97,;4.11,.34,;3.08,1.48,;3.85,2.82,;5.36,2.5,;6.5,3.53,;10.85,.97,;12.19,.2,;13.74,.2,;14.83,1.29,;10.85,2.51,;9.52,3.28,;12.19,3.28,)| Show InChI InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	6.93E+4	n/a	n/a	n/a	n/a	n/a	25
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2862DX0
					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM80643 ((6R,7S)-7-[[4-(2-amino-1-carboxy-2-keto-ethylidene...) Show SMILES CO[C@]1(NC(=O)C2SC(S2)=C(C(N)=O)C(O)=O)[C@H]2SCC(CSc3nnnn3C)=C(N2C1=O)C(O)=O |wU:17.32,2.2,wD:2.1,c:30,(12.4,-3.66,;13.74,-2.89,;13.74,-1.35,;15.28,-1.35,;16.05,-2.69,;15.27,-4.02,;17.59,-2.69,;17.59,-1.15,;19.13,-1.15,;19.13,-2.69,;20.22,-.07,;21.71,-.47,;22.8,.62,;22.1,-1.96,;19.82,1.42,;20.92,2.51,;18.34,1.82,;12.19,-1.34,;10.85,-2.11,;9.52,-1.34,;9.52,.2,;8.18,.97,;6.85,.2,;5.52,.97,;4.11,.34,;3.08,1.48,;3.85,2.82,;5.36,2.5,;6.5,3.53,;10.85,.97,;12.19,.2,;13.74,.2,;14.83,1.29,;10.85,2.51,;9.52,3.28,;12.19,3.28,)| Show InChI InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...				Toxicol Sci 118: 485-500 (2010) Article DOI: 10.1093/toxsci/kfq269 BindingDB Entry DOI: 10.7270/Q26Q20JN
					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 2 (Homo sapiens (Human))	BDBM80643 ((6R,7S)-7-[[4-(2-amino-1-carboxy-2-keto-ethylidene...) Show SMILES CO[C@]1(NC(=O)C2SC(S2)=C(C(N)=O)C(O)=O)[C@H]2SCC(CSc3nnnn3C)=C(N2C1=O)C(O)=O |wU:17.32,2.2,wD:2.1,c:30,(12.4,-3.66,;13.74,-2.89,;13.74,-1.35,;15.28,-1.35,;16.05,-2.69,;15.27,-4.02,;17.59,-2.69,;17.59,-1.15,;19.13,-1.15,;19.13,-2.69,;20.22,-.07,;21.71,-.47,;22.8,.62,;22.1,-1.96,;19.82,1.42,;20.92,2.51,;18.34,1.82,;12.19,-1.34,;10.85,-2.11,;9.52,-1.34,;9.52,.2,;8.18,.97,;6.85,.2,;5.52,.97,;4.11,.34,;3.08,1.48,;3.85,2.82,;5.36,2.5,;6.5,3.53,;10.85,.97,;12.19,.2,;13.74,.2,;14.83,1.29,;10.85,2.51,;9.52,3.28,;12.19,3.28,)| Show InChI InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 1 (Homo sapiens (Human))	BDBM80643 ((6R,7S)-7-[[4-(2-amino-1-carboxy-2-keto-ethylidene...) Show SMILES CO[C@]1(NC(=O)C2SC(S2)=C(C(N)=O)C(O)=O)[C@H]2SCC(CSc3nnnn3C)=C(N2C1=O)C(O)=O |wU:17.32,2.2,wD:2.1,c:30,(12.4,-3.66,;13.74,-2.89,;13.74,-1.35,;15.28,-1.35,;16.05,-2.69,;15.27,-4.02,;17.59,-2.69,;17.59,-1.15,;19.13,-1.15,;19.13,-2.69,;20.22,-.07,;21.71,-.47,;22.8,.62,;22.1,-1.96,;19.82,1.42,;20.92,2.51,;18.34,1.82,;12.19,-1.34,;10.85,-2.11,;9.52,-1.34,;9.52,.2,;8.18,.97,;6.85,.2,;5.52,.97,;4.11,.34,;3.08,1.48,;3.85,2.82,;5.36,2.5,;6.5,3.53,;10.85,.97,;12.19,.2,;13.74,.2,;14.83,1.29,;10.85,2.51,;9.52,3.28,;12.19,3.28,)| Show InChI InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM80643 ((6R,7S)-7-[[4-(2-amino-1-carboxy-2-keto-ethylidene...) Show SMILES CO[C@]1(NC(=O)C2SC(S2)=C(C(N)=O)C(O)=O)[C@H]2SCC(CSc3nnnn3C)=C(N2C1=O)C(O)=O |wU:17.32,2.2,wD:2.1,c:30,(12.4,-3.66,;13.74,-2.89,;13.74,-1.35,;15.28,-1.35,;16.05,-2.69,;15.27,-4.02,;17.59,-2.69,;17.59,-1.15,;19.13,-1.15,;19.13,-2.69,;20.22,-.07,;21.71,-.47,;22.8,.62,;22.1,-1.96,;19.82,1.42,;20.92,2.51,;18.34,1.82,;12.19,-1.34,;10.85,-2.11,;9.52,-1.34,;9.52,.2,;8.18,.97,;6.85,.2,;5.52,.97,;4.11,.34,;3.08,1.48,;3.85,2.82,;5.36,2.5,;6.5,3.53,;10.85,.97,;12.19,.2,;13.74,.2,;14.83,1.29,;10.85,2.51,;9.52,3.28,;12.19,3.28,)| Show InChI InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair
Multidrug resistance-associated protein 4 (Homo sapiens (Human))	BDBM80643 ((6R,7S)-7-[[4-(2-amino-1-carboxy-2-keto-ethylidene...) Show SMILES CO[C@]1(NC(=O)C2SC(S2)=C(C(N)=O)C(O)=O)[C@H]2SCC(CSc3nnnn3C)=C(N2C1=O)C(O)=O |wU:17.32,2.2,wD:2.1,c:30,(12.4,-3.66,;13.74,-2.89,;13.74,-1.35,;15.28,-1.35,;16.05,-2.69,;15.27,-4.02,;17.59,-2.69,;17.59,-1.15,;19.13,-1.15,;19.13,-2.69,;20.22,-.07,;21.71,-.47,;22.8,.62,;22.1,-1.96,;19.82,1.42,;20.92,2.51,;18.34,1.82,;12.19,-1.34,;10.85,-2.11,;9.52,-1.34,;9.52,.2,;8.18,.97,;6.85,.2,;5.52,.97,;4.11,.34,;3.08,1.48,;3.85,2.82,;5.36,2.5,;6.5,3.53,;10.85,.97,;12.19,.2,;13.74,.2,;14.83,1.29,;10.85,2.51,;9.52,3.28,;12.19,3.28,)| Show InChI InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair