Found 11 hits for monomerid = 8069 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
CDK2/CycE
(Homo sapiens (Human)) | BDBM8069
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 40 | 4...)Show InChI InChI=1S/C16H18N6S/c1-10-14(23-15(17)19-10)13-8-9-18-16(21-13)20-11-4-6-12(7-5-11)22(2)3/h4-9H,1-3H3,(H2,17,19)(H,18,20,21) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 700 | -8.53 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
Cyclacel Limited
| Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P... |
J Med Chem 47: 1662-75 (2004)
Article DOI: 10.1021/jm0309957 BindingDB Entry DOI: 10.7270/Q2H993DD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-Dependent Kinase 4 (CDK4)
(Homo sapiens (Human)) | BDBM8069
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 40 | 4...)Show InChI InChI=1S/C16H18N6S/c1-10-14(23-15(17)19-10)13-8-9-18-16(21-13)20-11-4-6-12(7-5-11)22(2)3/h4-9H,1-3H3,(H2,17,19)(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 900 | -8.38 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
Cyclacel Limited
| Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P... |
J Med Chem 47: 1662-75 (2004)
Article DOI: 10.1021/jm0309957 BindingDB Entry DOI: 10.7270/Q2H993DD |
More data for this Ligand-Target Pair | |
Cyclin-Dependent Kinase 2 (CDK2)
(Homo sapiens (Human)) | BDBM8069
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 40 | 4...)Show InChI InChI=1S/C16H18N6S/c1-10-14(23-15(17)19-10)13-8-9-18-16(21-13)20-11-4-6-12(7-5-11)22(2)3/h4-9H,1-3H3,(H2,17,19)(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | n/a | 190 | n/a | n/a | n/a | 7.5 | 25 |
CSAR
| Assay Description OctetRed |
CSAR 1: (2012)
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM8069
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 40 | 4...)Show InChI InChI=1S/C16H18N6S/c1-10-14(23-15(17)19-10)13-8-9-18-16(21-13)20-11-4-6-12(7-5-11)22(2)3/h4-9H,1-3H3,(H2,17,19)(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB D3R
| n/a | n/a | n/a | n/a | n/a | 0.0823 | n/a | n/a | n/a |
D3R
| Assay Description OctetRed_Method3 |
D3R 220: (2015)
BindingDB Entry DOI: 10.7270/Q21J98M7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM8069
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 40 | 4...)Show InChI InChI=1S/C16H18N6S/c1-10-14(23-15(17)19-10)13-8-9-18-16(21-13)20-11-4-6-12(7-5-11)22(2)3/h4-9H,1-3H3,(H2,17,19)(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB D3R
| n/a | n/a | n/a | n/a | n/a | n/a | 7.38E+4 | n/a | n/a |
D3R
| Assay Description OctetRed_Method3 |
D3R 219: (2015)
BindingDB Entry DOI: 10.7270/Q25B01BH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM8069
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 40 | 4...)Show InChI InChI=1S/C16H18N6S/c1-10-14(23-15(17)19-10)13-8-9-18-16(21-13)20-11-4-6-12(7-5-11)22(2)3/h4-9H,1-3H3,(H2,17,19)(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB D3R
| n/a | n/a | n/a | n/a | n/a | 0.0100 | n/a | n/a | n/a |
D3R
| Assay Description OctetRed_Method3 |
D3R 219: (2015)
BindingDB Entry DOI: 10.7270/Q25B01BH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM8069
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 40 | 4...)Show InChI InChI=1S/C16H18N6S/c1-10-14(23-15(17)19-10)13-8-9-18-16(21-13)20-11-4-6-12(7-5-11)22(2)3/h4-9H,1-3H3,(H2,17,19)(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB D3R
| n/a | n/a | n/a | 961 | n/a | n/a | n/a | n/a | n/a |
D3R
| Assay Description OctetRed_Method1 |
D3R 220: (2015)
BindingDB Entry DOI: 10.7270/Q21J98M7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM8069
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 40 | 4...)Show InChI InChI=1S/C16H18N6S/c1-10-14(23-15(17)19-10)13-8-9-18-16(21-13)20-11-4-6-12(7-5-11)22(2)3/h4-9H,1-3H3,(H2,17,19)(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB D3R
| n/a | n/a | n/a | n/a | n/a | n/a | 1.00E+5 | n/a | n/a |
D3R
| Assay Description OctetRed_Method3 |
D3R 220: (2015)
BindingDB Entry DOI: 10.7270/Q21J98M7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM8069
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 40 | 4...)Show InChI InChI=1S/C16H18N6S/c1-10-14(23-15(17)19-10)13-8-9-18-16(21-13)20-11-4-6-12(7-5-11)22(2)3/h4-9H,1-3H3,(H2,17,19)(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | n/a | 961 | n/a | n/a | n/a | 7.5 | 25 |
CSAR
| Assay Description OctetRed |
CSAR 1: (2012)
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM8069
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 40 | 4...)Show InChI InChI=1S/C16H18N6S/c1-10-14(23-15(17)19-10)13-8-9-18-16(21-13)20-11-4-6-12(7-5-11)22(2)3/h4-9H,1-3H3,(H2,17,19)(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | n/a | 4.79E+3 | n/a | n/a | n/a | 7.5 | 25 |
CSAR
| Assay Description Thermofluor |
CSAR 1: (2012)
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM8069
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 40 | 4...)Show InChI InChI=1S/C16H18N6S/c1-10-14(23-15(17)19-10)13-8-9-18-16(21-13)20-11-4-6-12(7-5-11)22(2)3/h4-9H,1-3H3,(H2,17,19)(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB D3R
| n/a | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a |
D3R
| Assay Description OctetRed_Method2 |
D3R 219: (2015)
BindingDB Entry DOI: 10.7270/Q25B01BH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |