BDBM81328 methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate, Compound E::methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate, E

SMILES: COC(=O)c1c(C)c(=O)[nH]c2ccccc12

InChI Key: InChIKey=ZNCUPPCJISULRA-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 81328   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1) (Homo sapiens (Human))	BDBM81328 (methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carbo...) Show SMILES COC(=O)c1c(C)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C12H11NO3/c1-7-10(12(15)16-2)8-5-3-4-6-9(8)13-11(7)14/h3-6H,1-2H3,(H,13,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	8.0	25
Brandeis University					Assay Description Enzyme inhibition assay using recombinant human IMPDH1 and IMPDH2 and C.parvum were expressed in guaB strains of escherichia coli.				Chem Biol 15: 70-7 (2008) Article DOI: 10.1016/j.chembiol.2007.12.010 BindingDB Entry DOI: 10.7270/Q2T1524X
					More data for this Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) (Homo sapiens (Human))	BDBM81328 (methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carbo...) Show SMILES COC(=O)c1c(C)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C12H11NO3/c1-7-10(12(15)16-2)8-5-3-4-6-9(8)13-11(7)14/h3-6H,1-2H3,(H,13,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	8.0	25
Brandeis University					Assay Description Enzyme inhibition assay using recombinant human IMPDH1 and IMPDH2 and C.parvum were expressed in guaB strains of escherichia coli.				Chem Biol 15: 70-7 (2008) Article DOI: 10.1016/j.chembiol.2007.12.010 BindingDB Entry DOI: 10.7270/Q2T1524X
					More data for this Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH) (Cryptosporidium parvum)	BDBM81328 (methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carbo...) Show SMILES COC(=O)c1c(C)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C12H11NO3/c1-7-10(12(15)16-2)8-5-3-4-6-9(8)13-11(7)14/h3-6H,1-2H3,(H,13,14)	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	8.0	25
Brandeis University					Assay Description Enzyme inhibition assay using recombinant human IMPDH1 and IMPDH2 and C.parvum were expressed in guaB strains of escherichia coli.				Chem Biol 15: 70-7 (2008) Article DOI: 10.1016/j.chembiol.2007.12.010 BindingDB Entry DOI: 10.7270/Q2T1524X
					More data for this Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH) (Streptococcus pyogenes)	BDBM81328 (methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carbo...) Show SMILES COC(=O)c1c(C)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C12H11NO3/c1-7-10(12(15)16-2)8-5-3-4-6-9(8)13-11(7)14/h3-6H,1-2H3,(H,13,14)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	8.0	25
Brandeis University					Assay Description Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).				Chem Biol 17: 1084-91 (2010) Article DOI: 10.1016/j.chembiol.2010.07.014 BindingDB Entry DOI: 10.7270/Q2GH9GF5
					More data for this Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH) (Helicobacter pylori (strain G27))	BDBM81328 (methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carbo...) Show SMILES COC(=O)c1c(C)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C12H11NO3/c1-7-10(12(15)16-2)8-5-3-4-6-9(8)13-11(7)14/h3-6H,1-2H3,(H,13,14)	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	8.0	25
Brandeis University					Assay Description Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).				Chem Biol 17: 1084-91 (2010) Article DOI: 10.1016/j.chembiol.2010.07.014 BindingDB Entry DOI: 10.7270/Q2GH9GF5
					More data for this Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH) (Borrelia burgdorferi)	BDBM81328 (methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carbo...) Show SMILES COC(=O)c1c(C)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C12H11NO3/c1-7-10(12(15)16-2)8-5-3-4-6-9(8)13-11(7)14/h3-6H,1-2H3,(H,13,14)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	8.0	25
Brandeis University					Assay Description Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).				Chem Biol 17: 1084-91 (2010) Article DOI: 10.1016/j.chembiol.2010.07.014 BindingDB Entry DOI: 10.7270/Q2GH9GF5
					More data for this Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH) (Cryptosporidium parvum)	BDBM81328 (methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carbo...) Show SMILES COC(=O)c1c(C)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C12H11NO3/c1-7-10(12(15)16-2)8-5-3-4-6-9(8)13-11(7)14/h3-6H,1-2H3,(H,13,14)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	8.0	25
Brandeis University					Assay Description Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).				Chem Biol 17: 1084-91 (2010) Article DOI: 10.1016/j.chembiol.2010.07.014 BindingDB Entry DOI: 10.7270/Q2GH9GF5
					More data for this Ligand-Target Pair