BDBM81428 N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-benzodiazol-1-yl]acetamide, Compound C91
SMILES: O=C(Cn1c(nc2ccccc12)-c1ccccn1)Nc1ccc2ccccc2c1
InChI Key: InChIKey=XYCMWFINXXFAFG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Inosine-5'-monophosphate dehydrogenase, probable (Cryptosporidium parvum) | BDBM81428 (N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-ben...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University Curated by ChEMBL | Assay Description Un-competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before IMP substrate addition by spectrophotometry | ACS Med Chem Lett 5: 846-50 (2014) Article DOI: 10.1021/ml500203p BindingDB Entry DOI: 10.7270/Q23J3FN3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase, probable (Cryptosporidium parvum) | BDBM81428 (N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-ben...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University Curated by ChEMBL | Assay Description Non-competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before NAD+ substrate addition by spectrophotometry | ACS Med Chem Lett 5: 846-50 (2014) Article DOI: 10.1021/ml500203p BindingDB Entry DOI: 10.7270/Q23J3FN3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5'-monophosphate dehydrogenase (Bacillus anthracis) | BDBM81428 (N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-ben...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University Curated by ChEMBL | Assay Description Non-competitive inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before NAD+ substrate addition by spectrophotometry | ACS Med Chem Lett 5: 846-50 (2014) Article DOI: 10.1021/ml500203p BindingDB Entry DOI: 10.7270/Q23J3FN3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Inosine-5'-monophosphate dehydrogenase (Bacillus anthracis) | BDBM81428 (N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-ben...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University Curated by ChEMBL | Assay Description Non-competitive inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before IMP substrate addition by spectrophotometry | ACS Med Chem Lett 5: 846-50 (2014) Article DOI: 10.1021/ml500203p BindingDB Entry DOI: 10.7270/Q23J3FN3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Inosine-5-monophosphate dehydrogenase (IMPDH) (Streptococcus pyogenes) | BDBM81428 (N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-ben...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Brandeis University | Assay Description Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD). | Chem Biol 17: 1084-91 (2010) Article DOI: 10.1016/j.chembiol.2010.07.014 BindingDB Entry DOI: 10.7270/Q2GH9GF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5-monophosphate dehydrogenase (IMPDH) (Cryptosporidium parvum) | BDBM81428 (N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-ben...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Brandeis University | Assay Description Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD). | Chem Biol 17: 1084-91 (2010) Article DOI: 10.1016/j.chembiol.2010.07.014 BindingDB Entry DOI: 10.7270/Q2GH9GF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) (Homo sapiens (Human)) | BDBM81428 (N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-ben...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University Curated by ChEMBL | Assay Description Inhibition of human IMPDH2 | Bioorg Med Chem Lett 22: 1985-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.029 BindingDB Entry DOI: 10.7270/Q2959JJB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5-monophosphate dehydrogenase (IMPDH) (Cryptosporidium parvum) | BDBM81428 (N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-ben...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University Curated by ChEMBL | Assay Description Inhibition of recombinant Cryptosporidium parvum IMPDH expressed in Escherichia coli assessed as NADH production preincubated for 5 mins by fluoresce... | Bioorg Med Chem Lett 22: 1985-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.029 BindingDB Entry DOI: 10.7270/Q2959JJB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5-monophosphate dehydrogenase (IMPDH) (Cryptosporidium parvum) | BDBM81428 (N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-ben...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University Curated by ChEMBL | Assay Description Inhibition of recombinant Cryptosporidium parvum IMPDH expressed in Escherichia coli assessed as NADH production preincubated for 5 mins by fluoresce... | Bioorg Med Chem Lett 22: 1985-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.029 BindingDB Entry DOI: 10.7270/Q2959JJB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inosine-5-monophosphate dehydrogenase (IMPDH) (Helicobacter pylori (strain G27)) | BDBM81428 (N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-ben...) | UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Brandeis University | Assay Description Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD). | Chem Biol 17: 1084-91 (2010) Article DOI: 10.1016/j.chembiol.2010.07.014 BindingDB Entry DOI: 10.7270/Q2GH9GF5 | |||||||||||
More data for this Ligand-Target Pair |