BindingDB PrimarySearch

BDBM81452 CAS_91533::Dimethindene::NSC_91533

SMILES: CC(C1=C(CCN(C)C)Cc2ccccc12)c1ccccn1

InChI Key: InChIKey=MVMQESMQSYOVGV-UHFFFAOYSA-N

Data: 8 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 81452
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H1 receptor (Homo sapiens (Human))	BDBM81452 (CAS_91533 \| Dimethindene \| NSC_91533) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	DrugBank Article PubMed	0.692	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg-University of Mainz Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine				J Med Chem 46: 856-67 (2003) Article DOI: 10.1021/jm020895l BindingDB Entry DOI: 10.7270/Q2XK8J83
Johannes Gutenberg-University of Mainz Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM81452 (CAS_91533 \| Dimethindene \| NSC_91533) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Proc Natl Acad Sci U S A 75: 6290-4 (1978) Article DOI: 10.1073/pnas.75.12.6290 BindingDB Entry DOI: 10.7270/Q2FN14P6
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM81452 (CAS_91533 \| Dimethindene \| NSC_91533) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	PubMed	45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Mainz Curated by ChEMBL					Assay Description Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.				Bioorg Med Chem Lett 11: 1241-3 (2001) BindingDB Entry DOI: 10.7270/Q21R6SP8
University of Mainz Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM81452 (CAS_91533 \| Dimethindene \| NSC_91533) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	PubMed	191	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Mainz Curated by ChEMBL					Assay Description Affinity for Muscarinic acetylcholine receptor M3 expressed in CHO cells by [3H]-NMS displacement.				Bioorg Med Chem Lett 11: 1241-3 (2001) BindingDB Entry DOI: 10.7270/Q21R6SP8
University of Mainz Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM81452 (CAS_91533 \| Dimethindene \| NSC_91533) Show SMILES Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	PubMed	263	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Mainz Curated by ChEMBL					Assay Description Affinity for Muscarinic acetylcholine receptor M1 expressed in CHO cells by [3H]NMS displacement.				Bioorg Med Chem Lett 11: 1241-3 (2001) BindingDB Entry DOI: 10.7270/Q21R6SP8
University of Mainz Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM81452 (CAS_91533 \| Dimethindene \| NSC_91533) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	PubMed	407	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Mainz Curated by ChEMBL					Assay Description Affinity for Muscarinic acetylcholine receptor M4 expressed in CHO cells by [3H]NMS displacement.				Bioorg Med Chem Lett 11: 1241-3 (2001) BindingDB Entry DOI: 10.7270/Q21R6SP8
University of Mainz Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM81452 (CAS_91533 \| Dimethindene \| NSC_91533) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	PubMed	794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Mainz Curated by ChEMBL					Assay Description Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement.				Bioorg Med Chem Lett 11: 1241-3 (2001) BindingDB Entry DOI: 10.7270/Q21R6SP8
University of Mainz Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-2 adrenergic receptor (Homo sapiens (Human))	BDBM81452 (CAS_91533 \| Dimethindene \| NSC_91533) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 12: 568-80 (1976) BindingDB Entry DOI: 10.7270/Q2ZK5F5P
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair