BindingDB PrimarySearch

BDBM81461 CAS_86-54-4::Hydralazine::Hydralazine (HZN)::NSC_3637

SMILES: NNc1nncc2ccccc12

InChI Key: InChIKey=RPTUSVTUFVMDQK-UHFFFAOYSA-N

Data: 6 KI 7 IC50 1 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 81461
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cholinesterase (Equus caballus (Horse))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Equus caballus (horse) serum butyrylcholinesterase (BChE) assessed as inhibition of BTCh hydrolysis by Ellman method				Citation and Details Article DOI: 10.1007/s00044-005-0140-0 BindingDB Entry DOI: 10.7270/Q2CJ8HD5
TBA					More data for this Ligand-Target Pair
Cholinesterase (Equus caballus (Horse))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article	5.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Equus caballus (horse) serum butyrylcholinesterase (BChE) assessed as inhibition of BTCh hydrolysis by Ellman method				Citation and Details Article DOI: 10.1007/s00044-005-0140-0 BindingDB Entry DOI: 10.7270/Q2CJ8HD5
TBA					More data for this Ligand-Target Pair
Acetylcholinesterase (Electrophorus electricus (Electric eel))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Electrophorus electricus (electric eel) acetylcholinesterase (AChE) assessed as inhibition of ATCh hydrolysis by Ellman method				Citation and Details Article DOI: 10.1007/s00044-005-0140-0 BindingDB Entry DOI: 10.7270/Q2CJ8HD5
TBA					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 13: 454-73 (1977) BindingDB Entry DOI: 10.7270/Q2TT4PFZ
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	5.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 13: 454-73 (1977) BindingDB Entry DOI: 10.7270/Q2TT4PFZ
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Acetylcholinesterase (Electrophorus electricus (Electric eel))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article	2.51E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Electrophorus electricus (electric eel) acetylcholinesterase (AChE) assessed as inhibition of ATCh hydrolysis by Ellman method				Citation and Details Article DOI: 10.1007/s00044-005-0140-0 BindingDB Entry DOI: 10.7270/Q2CJ8HD5
TBA					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...				Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Myeloperoxidase (Homo sapiens (Human))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Libre de Bruxelles Curated by ChEMBL					Assay Description Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed b...				J Med Chem 60: 6563-6586 (2017) Article DOI: 10.1021/acs.jmedchem.7b00285 BindingDB Entry DOI: 10.7270/Q27D2XD7
Universit£ Libre de Bruxelles Curated by ChEMBL					More data for this Ligand-Target Pair
Lactoperoxidase (LPO) (Bos taurus (Bovine))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Libre de Bruxelles Curated by ChEMBL					Assay Description Inhibition of bovine milk LPO assessed as reduction in NaOSCN production in presence of H2O2/NaSCN after 5 mins				J Med Chem 60: 6563-6586 (2017) Article DOI: 10.1021/acs.jmedchem.7b00285 BindingDB Entry DOI: 10.7270/Q27D2XD7
Universit£ Libre de Bruxelles Curated by ChEMBL					More data for this Ligand-Target Pair
Myeloperoxidase (MPO) (Homo sapiens (Human))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Libre de Bruxelles (ULB) Curated by ChEMBL					Assay Description Inhibition of human MPO				ACS Med Chem Lett 8: 206-210 (2017) Article DOI: 10.1021/acsmedchemlett.6b00417 BindingDB Entry DOI: 10.7270/Q28K7C3H
Universit£ Libre de Bruxelles (ULB) Curated by ChEMBL					More data for this Ligand-Target Pair
Myeloperoxidase (MPO) (Homo sapiens (Human))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Libre de Bruxelles (ULB) Curated by ChEMBL					Assay Description Irreversible inhibition of MPO (unknown origin)				ACS Med Chem Lett 8: 206-210 (2017) Article DOI: 10.1021/acsmedchemlett.6b00417 BindingDB Entry DOI: 10.7270/Q28K7C3H
Universit£ Libre de Bruxelles (ULB) Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group I member 2 (Rattus norvegicus)	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a
National Institutes of Health Chemical Genomics Center Curated by ChEMBL					Assay Description Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis				Drug Metab Dispos 39: 151-9 (2010) Article DOI: 10.1124/dmd.110.035105 BindingDB Entry DOI: 10.7270/Q2JS9S5P
					More data for this Ligand-Target Pair
8-Oxoguanine DNA glycosylase-1 (OGG1) (Homo sapiens (Human))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 �L of OGG1 (125 nM) was mixed with 1 �L of inhibitor. In a separate tube, 1 �L of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
Oregon Health & Science University					More data for this Ligand-Target Pair
Myeloperoxidase (Homo sapiens (Human))	BDBM81461 (CAS_86-54-4 \| Hydralazine \| Hydralazine (HZN) \| NS...) Show SMILES NNc1nncc2ccccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Libre de Bruxelles Curated by ChEMBL					Assay Description Inhibition of recombinant MPO (unknown origin) assessed as reduction in LDL oxidation in presence of H2O2 and HCl after 5 mins by ELISA				J Med Chem 60: 6563-6586 (2017) Article DOI: 10.1021/acs.jmedchem.7b00285 BindingDB Entry DOI: 10.7270/Q27D2XD7
Universit£ Libre de Bruxelles Curated by ChEMBL					More data for this Ligand-Target Pair