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SMILES: CCCc1cc(=O)oc2c(C(=O)N3CCCc4ccccc34)c(OC)cc(OC)c12

InChI Key: InChIKey=LRPUQCTZOSTSGL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 81544   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha


(Homo sapiens (Human))		BDBM81544
PNG
(BNS-22)
Show SMILES CCCc1cc(=O)oc2c(C(=O)N3CCCc4ccccc34)c(OC)cc(OC)c12
Show InChI InChI=1S/C24H25NO5/c1-4-8-16-13-20(26)30-23-21(16)18(28-2)14-19(29-3)22(23)24(27)25-12-7-10-15-9-5-6-11-17(15)25/h5-6,9,11,13-14H,4,7-8,10,12H2,1-3H3
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Article
PubMed
n/an/a 2.80E+3n/an/an/an/a7.54



RIKEN Advanced Science Institute



Assay Description
In vitro inhibition of TOP2 alpha activity by BNS derivatives.

Chem Biol 18: 743-51 (2011)


Article DOI: 10.1016/j.chembiol.2011.03.012
BindingDB Entry DOI: 10.7270/Q2N58JWJ
More data for this
Ligand-Target Pair