BDBM81632 BZD Scaffold, 2

SMILES: CC(C)c1ccc2NC(=O)C(N(C(C([O-])=O)c3ccc(Cl)cc3)C(=O)c2c1)c1ccc(Cl)cc1

InChI Key: InChIKey=FSGBJNDTAIPOPY-UHFFFAOYSA-M

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 81632   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53 binding protein (Homo sapiens (Human))	BDBM81632 (BZD Scaffold, 2) Show SMILES CC(C)c1ccc2NC(=O)C(N(C(C([O-])=O)c3ccc(Cl)cc3)C(=O)c2c1)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H22Cl2N2O4/c1-14(2)17-7-12-21-20(13-17)25(32)30(23(26(33)34)16-5-10-19(28)11-6-16)22(24(31)29-21)15-3-8-18(27)9-4-15/h3-14,22-23H,1-2H3,(H,29,31)(H,33,34)/p-1	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development					Assay Description Binding assay using 1,4-benzodiazepine-2,5-dione (BZD) scaffold and HDM2-p53 protein.				Chem Biol Drug Des 67: 201-5 (2006) Article DOI: 10.1111/j.1747-0285.2006.00365.x BindingDB Entry DOI: 10.7270/Q2BP018M
					More data for this Ligand-Target Pair