BDBM81634 BZD Scaffold, 4

SMILES: [O-]C(=O)C(N1C(c2ccc(cc2)C(F)(F)F)C(=O)Nc2ccc(I)cc2C1=O)c1ccccc1

InChI Key: InChIKey=OUJPKXOGQQVHGA-UHFFFAOYSA-M

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 81634   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53 binding protein (Homo sapiens (Human))	BDBM81634 (BZD Scaffold, 4) Show SMILES [O-]C(=O)C(N1C(c2ccc(cc2)C(F)(F)F)C(=O)Nc2ccc(I)cc2C1=O)c1ccccc1 Show InChI InChI=1S/C24H16F3IN2O4/c25-24(26,27)15-8-6-14(7-9-15)19-21(31)29-18-11-10-16(28)12-17(18)22(32)30(19)20(23(33)34)13-4-2-1-3-5-13/h1-12,19-20H,(H,29,31)(H,33,34)/p-1	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development					Assay Description Binding assay using 1,4-benzodiazepine-2,5-dione (BZD) scaffold and HDM2-p53 protein.				Chem Biol Drug Des 67: 201-5 (2006) Article DOI: 10.1111/j.1747-0285.2006.00365.x BindingDB Entry DOI: 10.7270/Q2BP018M
					More data for this Ligand-Target Pair