BindingDB PrimarySearch

BDBM81900 AQ-RA 741::CAS_129989::NSC_129989

SMILES: CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1

InChI Key: InChIKey=BCUGCHZRMKTPMU-UHFFFAOYSA-N

Data: 21 KI 2 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 81900
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Muscarinic acetylcholine receptor M2 (RAT)	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University Medical Center Curated by ChEMBL					Assay Description Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart				J Med Chem 36: 162-5 (1993) BindingDB Entry DOI: 10.7270/Q22R3TWJ
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	4.27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Neurological Disorders and Stroke Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 727-33 (1991) BindingDB Entry DOI: 10.7270/Q2VD6WZ3
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay				J Med Chem 62: 5358-5369 (2019) Article DOI: 10.1021/acs.jmedchem.8b01967
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells				J Med Chem 62: 5358-5369 (2019) Article DOI: 10.1021/acs.jmedchem.8b01967
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	5.01	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by PDSP K_i Database									J Med Chem 36: 3734-7 (1993) Article DOI: 10.1021/jm00075a032 BindingDB Entry DOI: 10.7270/Q2W957Q0
University of Bologna Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	6.46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Neurological Disorders and Stroke Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 727-33 (1991) BindingDB Entry DOI: 10.7270/Q2VD6WZ3
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]-NMS from human muscarinic M4 receptor expressed in stable CHO-K1 cells by radioligand binding assay				J Med Chem 62: 5358-5369 (2019) Article DOI: 10.1021/acs.jmedchem.8b01967
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Binding affinity to muscarinic M4 receptor (unknown origin) expressed in CHO cells				J Med Chem 62: 5358-5369 (2019) Article DOI: 10.1021/acs.jmedchem.8b01967
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by PDSP K_i Database									J Med Chem 36: 3734-7 (1993) Article DOI: 10.1021/jm00075a032 BindingDB Entry DOI: 10.7270/Q2W957Q0
University of Bologna Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	25.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by PDSP K_i Database									J Med Chem 36: 3734-7 (1993) Article DOI: 10.1021/jm00075a032 BindingDB Entry DOI: 10.7270/Q2W957Q0
University of Bologna Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	28.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Neurological Disorders and Stroke Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 727-33 (1991) BindingDB Entry DOI: 10.7270/Q2VD6WZ3
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]-NMS from human muscarinic M1 receptor expressed in stable CHO-K1 cells by radioligand binding assay				J Med Chem 62: 5358-5369 (2019) Article DOI: 10.1021/acs.jmedchem.8b01967
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University Medical Center Curated by ChEMBL					Assay Description Binding affinity by the displacement of [3H]NMS binding to A9 L cells transfected with muscarinic M1 receptor of rat brain				J Med Chem 36: 162-5 (1993) BindingDB Entry DOI: 10.7270/Q22R3TWJ
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Binding affinity to muscarinic M1 receptor (unknown origin) expressed in CHO cells				J Med Chem 62: 5358-5369 (2019) Article DOI: 10.1021/acs.jmedchem.8b01967
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 and M3 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]-NMS from human muscarinic M3 receptor expressed in stable CHO-K1 cells by radioligand binding assay				J Med Chem 62: 5358-5369 (2019) Article DOI: 10.1021/acs.jmedchem.8b01967
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	63.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Neurological Disorders and Stroke Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 727-33 (1991) BindingDB Entry DOI: 10.7270/Q2VD6WZ3
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 and M3 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Binding affinity to muscarinic M3 receptor (unknown origin) expressed in CHO cells				J Med Chem 62: 5358-5369 (2019) Article DOI: 10.1021/acs.jmedchem.8b01967
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (RAT)	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	158	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by PDSP K_i Database									J Med Chem 36: 3734-7 (1993) Article DOI: 10.1021/jm00075a032 BindingDB Entry DOI: 10.7270/Q2W957Q0
University of Bologna Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	832	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Neurological Disorders and Stroke Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 727-33 (1991) BindingDB Entry DOI: 10.7270/Q2VD6WZ3
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	832	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]-NMS from human muscarinic M5 receptor expressed in stable CHO-K1 cells by radioligand binding assay				J Med Chem 62: 5358-5369 (2019) Article DOI: 10.1021/acs.jmedchem.8b01967
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Binding affinity to muscarinic M5 receptor (unknown origin) expressed in CHO cells				J Med Chem 62: 5358-5369 (2019) Article DOI: 10.1021/acs.jmedchem.8b01967
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	9.33	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by ChEMBL					Assay Description Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]				J Med Chem 37: 3363-72 (1994) BindingDB Entry DOI: 10.7270/Q21V5G5G
University of Bologna Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Cavia porcellus)	BDBM81900 (AQ-RA 741 \| CAS_129989 \| NSC_129989) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by ChEMBL					Assay Description Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist]				J Med Chem 37: 3363-72 (1994) BindingDB Entry DOI: 10.7270/Q21V5G5G
University of Bologna Curated by ChEMBL					More data for this Ligand-Target Pair