BDBM81986 3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrochloride::CAS_173870::CHEMBL545000::NSC_173870::SKF 75670
SMILES: CN1CCc2cc(O)c(O)cc2C(C1)c1ccccc1
InChI Key: InChIKey=LIHCKGZEDBNUJG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Dopamine D1 receptor (Mus musculus (Mouse)) | BDBM81986 (3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVO Industri A/S Curated by PDSP Ki Database | Eur J Pharmacol 146: 113-20 (1988) Article DOI: 10.1016/0014-2999(88)90492-x BindingDB Entry DOI: 10.7270/Q21R6P1H | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM81986 (3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1 | J Med Chem 34: 3366-71 (1992) BindingDB Entry DOI: 10.7270/Q26H4J17 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Mus musculus (Mouse)) | BDBM81986 (3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 840 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVO Industri A/S Curated by PDSP Ki Database | Eur J Pharmacol 146: 113-20 (1988) Article DOI: 10.1016/0014-2999(88)90492-x BindingDB Entry DOI: 10.7270/Q21R6P1H | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM81986 (3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description The compound was evaluated for the binding affinity towards dopamine receptor D2 at high affinity state. | J Med Chem 34: 3366-71 (1992) BindingDB Entry DOI: 10.7270/Q26H4J17 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM81986 (3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
ShanghaiTech University Curated by ChEMBL | Assay Description Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins... | J Med Chem 61: 9841-9878 (2018) Article DOI: 10.1021/acs.jmedchem.8b00435 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM81986 (3-Methyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a |
ShanghaiTech University Curated by ChEMBL | Assay Description Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation aft... | J Med Chem 61: 9841-9878 (2018) Article DOI: 10.1021/acs.jmedchem.8b00435 | |||||||||||
More data for this Ligand-Target Pair |