BindingDB PrimarySearch

null

SMILES: CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1

InChI Key: InChIKey=PSIFNNKUMBGKDQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 80 hits for monomerid = 82258
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma US Inc. Curated by ChEMBL					Assay Description Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA				ACS Med Chem Lett 10: 86-91 (2019) Article DOI: 10.1021/acsmedchemlett.8b00462 BindingDB Entry DOI: 10.7270/Q2D50R6V
Theravance Biopharma US Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor A/B (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars		5.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding against Angiotensin II receptor in a radioligand binding assay using [125I]-Sar1-Ile8 angiotensin-II as radioligand in rat adrenal cortical m...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C53P05
TBA					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 re...				J Med Chem 59: 1925-45 (2016) Article DOI: 10.1021/acs.jmedchem.5b01495 BindingDB Entry DOI: 10.7270/Q2V69MGK
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor A (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	12.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 272: 963-9 (1995) BindingDB Entry DOI: 10.7270/Q2J38R2N
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor A (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Donghua University Curated by ChEMBL					Assay Description Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method				Bioorg Med Chem 24: 2023-31 (2016) Article DOI: 10.1016/j.bmc.2016.03.028 BindingDB Entry DOI: 10.7270/Q2XW4MQB
Donghua University Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor A (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against angiotensin II receptor from rat liver; n=8				J Med Chem 36: 2676-88 (1993) BindingDB Entry DOI: 10.7270/Q2QF8TGV
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver				J Med Chem 35: 3714-7 (1992) BindingDB Entry DOI: 10.7270/Q2H41QCN
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation counting				J Med Chem 59: 1925-45 (2016) Article DOI: 10.1021/acs.jmedchem.5b01495 BindingDB Entry DOI: 10.7270/Q2V69MGK
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Research and Development Ltd. Curated by ChEMBL					Assay Description Tested for in vitro binding affinity against angiotensin II receptor of rat liver				J Med Chem 37: 3108-20 (1994) Article DOI: 10.1021/jm00045a016 BindingDB Entry DOI: 10.7270/Q21R6T7V
Glaxo Research and Development Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	33.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Pharmaceuticals Limited Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1042-53 (1995) BindingDB Entry DOI: 10.7270/Q20G3HN9
					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	45.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Pharmaceuticals Limited Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1042-53 (1995) BindingDB Entry DOI: 10.7270/Q20G3HN9
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	95	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membra...				J Med Chem 35: 4751-63 (1993) BindingDB Entry DOI: 10.7270/Q2VH5PFJ
					More data for this Ligand-Target Pair
Solute carrier organic anion transporter family member 1B1 (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
KU Leuven Curated by ChEMBL					Assay Description Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells				Mol Pharmacol 83: 1257-67 (2013) Article DOI: 10.1124/mol.112.084152 BindingDB Entry DOI: 10.7270/Q2TB18BP
KU Leuven Curated by ChEMBL					More data for this Ligand-Target Pair
Solute carrier organic anion transporter family member 1B3 (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	890	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
KU Leuven Curated by ChEMBL					Assay Description Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells				Mol Pharmacol 83: 1257-67 (2013) Article DOI: 10.1124/mol.112.084152 BindingDB Entry DOI: 10.7270/Q2TB18BP
KU Leuven Curated by ChEMBL					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Pharmaceuticals Limited Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1042-53 (1995) BindingDB Entry DOI: 10.7270/Q20G3HN9
					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (Sus scrofa)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Displacement of [125I]angiotensin 2 from AT2 receptor in pig uterus membrane after 1.5 hrs by gamma counting				Bioorg Med Chem 18: 4570-90 (2010) Article DOI: 10.1016/j.bmc.2010.03.064 BindingDB Entry DOI: 10.7270/Q2VD70F0
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Angiotensin-converting enzyme 2 (BOVINE)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington State University Curated by PDSP K_i Database									J Pharmacol Exp Ther 291: 1242-9 (1999) BindingDB Entry DOI: 10.7270/Q2377783
Washington State University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 272: 963-9 (1995) BindingDB Entry DOI: 10.7270/Q2J38R2N
					More data for this Ligand-Target Pair
Angiotensin-converting enzyme 2 (BOVINE)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington State University Curated by PDSP K_i Database									J Pharmacol Exp Ther 291: 1242-9 (1999) BindingDB Entry DOI: 10.7270/Q2377783
Washington State University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a
The M. S. University of Baroda Curated by ChEMBL					Assay Description Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings				Bioorg Med Chem 18: 8418-56 (2010) Article DOI: 10.1016/j.bmc.2010.10.043 BindingDB Entry DOI: 10.7270/Q2H70G3T
The M. S. University of Baroda Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings				Bioorg Med Chem Lett 4: 1297-1302 (1994) Article DOI: 10.1016/S0960-894X(01)80348-6 BindingDB Entry DOI: 10.7270/Q2G44QRD
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of guinea pig ventricular Phosphodiesterase 3 (PDE 3)				Bioorg Med Chem Lett 8: 505-10 (1998) BindingDB Entry DOI: 10.7270/Q2XD13VZ
Rhône-Poulenc Rorer Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory effect in cAMP-specific Phosphodiesterase 4 (PDE 4) isolated from guinea pig ventricular tissue.				Bioorg Med Chem Lett 8: 505-10 (1998) BindingDB Entry DOI: 10.7270/Q2XD13VZ
Rhône-Poulenc Rorer Curated by ChEMBL					More data for this Ligand-Target Pair
Solute carrier organic anion transporter family member 1B1 (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	288	n/a	n/a	n/a	n/a	n/a	n/a
KU Leuven Curated by ChEMBL					Assay Description pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells				Mol Pharmacol 83: 1257-67 (2013) Article DOI: 10.1124/mol.112.084152 BindingDB Entry DOI: 10.7270/Q2TB18BP
KU Leuven Curated by ChEMBL					More data for this Ligand-Target Pair
Solute carrier organic anion transporter family member 1B3 (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
KU Leuven Curated by ChEMBL					Assay Description pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells				Mol Pharmacol 83: 1257-67 (2013) Article DOI: 10.1124/mol.112.084152 BindingDB Entry DOI: 10.7270/Q2TB18BP
KU Leuven Curated by ChEMBL					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Binding affinity to type-2 angiotensin-2 receptor (unknown origin)				Bioorg Med Chem Lett 26: 1355-9 (2016) Article DOI: 10.1016/j.bmcl.2015.10.084 BindingDB Entry DOI: 10.7270/Q2SN0BT6
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor A (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Donghua University Curated by ChEMBL					Assay Description Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method				Bioorg Med Chem 24: 2023-31 (2016) Article DOI: 10.1016/j.bmc.2016.03.028 BindingDB Entry DOI: 10.7270/Q2XW4MQB
Donghua University Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
National Hellenic Research Foundation Curated by ChEMBL					Assay Description Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method				Bioorg Med Chem 24: 4444-4451 (2016) Article DOI: 10.1016/j.bmc.2016.07.047 BindingDB Entry DOI: 10.7270/Q20P11ZV
National Hellenic Research Foundation Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	61.1	n/a	n/a	n/a	n/a	n/a	n/a
Kyung Hee University Curated by ChEMBL					Assay Description Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...				Bioorg Med Chem Lett 22: 1649-54 (2012) Article DOI: 10.1016/j.bmcl.2011.12.116 BindingDB Entry DOI: 10.7270/Q22R3S48
Kyung Hee University Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16.2	n/a	n/a	n/a	n/a	n/a	n/a
Beijing Institute of Technology Curated by ChEMBL					Assay Description Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting				Eur J Med Chem 49: 183-90 (2012) Article DOI: 10.1016/j.ejmech.2012.01.009 BindingDB Entry DOI: 10.7270/Q29K4BPW
Beijing Institute of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Beijing Institute of Technology Curated by ChEMBL					Assay Description Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting				Eur J Med Chem 49: 183-90 (2012) Article DOI: 10.1016/j.ejmech.2012.01.009 BindingDB Entry DOI: 10.7270/Q29K4BPW
Beijing Institute of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Angiotensin-converting enzyme (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
University of Queensland Curated by ChEMBL					Assay Description Inhibitory activity against angiotensin I converting enzyme (ACE)				J Med Chem 43: 305-41 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2JD4XH4
University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor				J Med Chem 47: 5995-6008 (2004) Article DOI: 10.1021/jm049715t BindingDB Entry DOI: 10.7270/Q29Z95PH
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a
Beijing Institute of Technology Curated by ChEMBL					Assay Description Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 6...				Eur J Med Chem 49: 183-90 (2012) Article DOI: 10.1016/j.ejmech.2012.01.009 BindingDB Entry DOI: 10.7270/Q29K4BPW
Beijing Institute of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Multidrug and toxin extrusion protein 1 (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay				J Med Chem 56: 781-95 (2013) Article DOI: 10.1021/jm301302s BindingDB Entry DOI: 10.7270/Q2F76DWZ
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor A (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Siena Curated by ChEMBL					Assay Description Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane				J Med Chem 51: 2137-46 (2008) Article DOI: 10.1021/jm7011563 BindingDB Entry DOI: 10.7270/Q20P10X0
Universit£ di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Type-2 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Antagonist activity at angiotensin 2 receptor				J Med Chem 54: 2529-91 (2011) Article DOI: 10.1021/jm1013693 BindingDB Entry DOI: 10.7270/Q24M95PH
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
Universit£ di Siena Curated by ChEMBL					Assay Description Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins				J Med Chem 51: 2137-46 (2008) Article DOI: 10.1021/jm7011563 BindingDB Entry DOI: 10.7270/Q20P10X0
Universit£ di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	3.72	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings				Bioorg Med Chem Lett 4: 173-176 (1994) Article DOI: 10.1016/S0960-894X(01)81142-2 BindingDB Entry DOI: 10.7270/Q2G44RFS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	1.58	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity against Angiotensin II receptor in rabbit aorta rings				Bioorg Med Chem Lett 4: 87-92 (1994) Article DOI: 10.1016/S0960-894X(01)81127-6 BindingDB Entry DOI: 10.7270/Q2BC40QF
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Bos taurus)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex				Bioorg Med Chem 20: 4661-7 (2012) Article DOI: 10.1016/j.bmc.2012.06.011 BindingDB Entry DOI: 10.7270/Q2G73FS6
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.62	n/a	n/a	n/a	n/a	n/a	n/a
University of Patras Curated by ChEMBL					Assay Description Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting				Eur J Med Chem 55: 358-74 (2012) Article DOI: 10.1016/j.ejmech.2012.07.040 BindingDB Entry DOI: 10.7270/Q23B617T
University of Patras Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of Patras Curated by ChEMBL					Assay Description Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting				Eur J Med Chem 55: 358-74 (2012) Article DOI: 10.1016/j.ejmech.2012.07.040 BindingDB Entry DOI: 10.7270/Q23B617T
University of Patras Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16.2	n/a	n/a	n/a	n/a	n/a	n/a
School of Chemical Engineering& the Environment Curated by ChEMBL					Assay Description Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting				Bioorg Med Chem 20: 4208-16 (2012) Article DOI: 10.1016/j.bmc.2012.05.056 BindingDB Entry DOI: 10.7270/Q2GT5P7J
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a
School of Chemical Engineering& the Environment Curated by ChEMBL					Assay Description Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post ...				Bioorg Med Chem 20: 4208-16 (2012) Article DOI: 10.1016/j.bmc.2012.05.056 BindingDB Entry DOI: 10.7270/Q2GT5P7J
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
School of Chemical Engineering& the Environment Curated by ChEMBL					Assay Description Inhibition of angiotensin AT1 receptor				Bioorg Med Chem 20: 4208-16 (2012) Article DOI: 10.1016/j.bmc.2012.05.056 BindingDB Entry DOI: 10.7270/Q2GT5P7J
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
E. I. du Pont de Nemours& Company, Inc. Curated by ChEMBL					Assay Description Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane				J Med Chem 34: 2525-47 (1991) BindingDB Entry DOI: 10.7270/Q2QN690P
E. I. du Pont de Nemours& Company, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1/Type-2 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Exploratory Chemistry Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Angiotensin receptor from rabbit aorta				J Med Chem 34: 2919-22 (1991) BindingDB Entry DOI: 10.7270/Q26Q20H6
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive inhibition of Angiotensin II receptor binding of radiolabeled AII to rat adrenal glomerulosa tissue by 50%				Citation and Details BindingDB Entry DOI: 10.7270/Q2Z03B9M
TBA					More data for this Ligand-Target Pair
Platelet glycoprotein VI (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Academy of Scientific and Innovative Research Curated by ChEMBL					Assay Description Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation preincubated for 5 ...				J Med Chem 60: 322-337 (2017) Article DOI: 10.1021/acs.jmedchem.6b01360 BindingDB Entry DOI: 10.7270/Q24T6MJ1
					More data for this Ligand-Target Pair

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